ReviewBiochimica et biophysica acta2009
Telomeres do the (un)twist: helicase actions at chromosome termini.
Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- EXO1 resection at G-quadruplex structures facilitates resolution and replication.Nucleic acids research · 2020Article
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin.PloS one · 2019Article
- Telomerase Regulation from Beginning to the End.Genes · 2016Review
- BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.The Journal of cell biology · 2015Article
- Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.The Journal of biological chemistry · 2014Article
- Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.The Journal of biological chemistry · 2013Article
- Timeless preserves telomere length by promoting efficient DNA replication through human telomeres.Cell cycle (Georgetown, Tex.) · 2012Article
- Genome-wide comprehensive analysis of human helicases.Communicative & integrative biology · 2011Article
- Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.The EMBO journal · 2010Article
- The choanoflagellate Monosiga brevicollis karyotype revealed by the genome sequence: telomere-linked helicase genes resemble those of some fungi.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Telomeres play critical roles in protecting genome stability, and their dysfunction contributes to cancer and age-related degenerative diseases. The precise architecture of telomeres, including their single-stranded 3' overhangs, bound proteins, and ability to form unusual secondary structures such as t-loops, is central to their function and thus requires careful processing by diverse factors. Furthermore, telomeres provide unique challenges to the DNA replication and recombination machinery, and are particularly suited for extension by the telomerase reverse transcriptase. Helicases use the energy from NTP hydrolysis to track along DNA and disrupt base pairing. Here we review current findings concerning how helicases modulate several aspects of telomere form and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.