Evidence map›Paper›PMID 19245801›Full record

ReviewBrain research2009

Feathers and fins: non-mammalian models for hair cell regeneration.

Heather R Brignull, David W Raible, Jennifer S Stone

Abstract readReview
In one paragraph

Review in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Hair Cell Regeneration: From Animals to Humans.Clinical and experimental otorhinolaryngology · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  15. Article
  16. Regeneration enhancers: a field in development.American journal of physiology. Cell physiology · 2022
    Review
  17. Article
  18. Article
  19. Cochlear Development; New Tools and Approaches.Frontiers in cell and developmental biology · 2022
    Review
  20. Frontiers in molecular neuroscience · 2022
    Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heather R BrignullDepartment of Biological Structure, University of Washington, WA 98195-7420, USA. brignull@u.washington.edu
David W Raible
Jennifer S Stone

Funding

UNIVERSITY OF WASHINGTON RESEARCH CORE CENTERP30DC004661 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W, STONE, JENNIFER S. · 2000 to 2014
$11.1M
Genetics of Zebrafish Hair Cell ToxicityR01DC005987 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 2003 to 2023
$9.8M
Auditory Neuroscience Traning ProgramT32DC005361 · NIDCD · UNIVERSITY OF WASHINGTON · PI Adrian KC Lee, DAVID J PERKEL · 2002 to 2026
$8.8M
Hair Cell Regeneration: Molecular RegulationR01DC003696 · NIDCD · UNIVERSITY OF WASHINGTON · PI STONE, JENNIFER S. · 2003 to 2011
$2.5M
Genetic analysis of hair cell regeneration in zebrafishR21DC008973 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 2007 to 2008
$426k
HAIR CELL REGENERATION--INTERCELLULAR REGULATIONR29DC003696 · NIDCD · UNIVERSITY OF WASHINGTON · PI STONE, JENNIFER S. · 1998 to 2002
$329k
Hair Cell Regeneration: Molecular RegulationR55DC003696 · NIDCD · UNIVERSITY OF WASHINGTON · PI STONE, JENNIFER S. · 2013 to 2013
$100k
NIDCD NIH HHS DC005987NIDCD NIH HHS DC008973NIDCD NIH HHS DC03696NIDCD NIH HHS DC04661NIDCD NIH HHS DC05361NIDCD NIH HHS P30 DC004661NIDCD NIH HHS R01 DC003696NIDCD NIH HHS R01 DC005987NIDCD NIH HHS R21 DC008973NIDCD NIH HHS R29 DC003696NIDCD NIH HHS R55 DC003696NIDCD NIH HHS T32 DC005361
6 · The paper itself

Abstract

Death of mechanosensory cells in the inner ear results in two profound disabilities: hearing loss and balance disorders. Although mammals lack the capacity to regenerate hair cells, recent studies in mice and other rodents have offered valuable insight into strategies for stimulating hair cell regeneration in mammals. Investigations of model organisms that retain the ability to form new hair cells after embryogenesis, such as fish and birds, are equally important and have provided clues as to the cellular and molecular mechanisms that may block hair cell regeneration in mammals. Here, we summarize studies on hair cell regeneration in the chicken and the zebrafish, discuss specific advantages of each model, and propose future directions for the use of non-mammalian models in understanding hair cell regeneration.

Indexed as

Models, AnimalAnimalsCell DifferentiationCell ProliferationChickensHair Cells, AuditoryMiceRegenerationZebrafish

Identifiers

PMID19245801
PMCPMC2700174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.