ReviewBrain research2009
Little but loud: small RNAs have a resounding affect on ear development.
Review in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Sensational MicroRNAs: Neurosensory Roles of the MicroRNA-183 Family.Molecular neurobiology · 2020Review
- Circulating Serum miRNA-205 as a Diagnostic Biomarker for Ototoxicity in Mice Treated with Aminoglycoside Antibiotics.International journal of molecular sciences · 2018Article
- MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness.Journal of audiology & otology · 2016Review
- The microRNA-183 cluster: the family that plays together stays together.Nucleic acids research · 2015Review
- Sensory hair cell death and regeneration in fishes.Frontiers in cellular neuroscience · 2015Review
- An expanded Notch-Delta model exhibiting long-range patterning and incorporating MicroRNA regulation.PLoS computational biology · 2014Article
- The genetics of hair cell development and regeneration.Annual review of neuroscience · 2013Review
- Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss.PloS one · 2013Article
- MicroRNAs in inner ear biology and pathogenesis.Hearing research · 2012Review
- Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Regeneration of Hair Cells: Making Sense of All the Noise.Pharmaceuticals (Basel, Switzerland) · 2011Article
- MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Evolution of microRNAs and the diversification of species.Genome biology and evolution · 2011Article
- MicroRNAs in hair cell development and deafness.Current opinion in otolaryngology & head and neck surgery · 2010Article
- Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation.PloS one · 2010Article
- Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.The Journal of biological chemistry · 2010Article
- MicroRNAs sound off.Genome medicine · 2009Article
- Evolution of electrosensory ampullary organs: conservation of Eya4 expression during lateral line development in jawed vertebrates.Evolution & developmentArticle
- MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The impact of small RNA function has resonated throughout nearly every aspect of eukaryotic biology and captured the varied interests of researchers, whether they are endeavoring to understand the basis of development and disease or seeking novel therapeutic targets and tools. The genetic regulatory roles of microRNAs (miRNAs) are particularly interesting given that these often highly conserved factors post-transcriptionally silence many complementary target genes by inhibiting messenger RNA translation. In this regard, miRNAs can be considered as counterparts to transcription factors, the ensemble of which establishes the set of expressed genes that define the characteristics of a specific cell type. In this review, evidence supporting a resounding role for small RNAs in development and maturation of sensory epithelia in the mouse inner ear will be considered with an emphasis on the contribution of one hair cell miRNA family (miR-183, miR-96, and miR-182). Although there is much yet to be explored in this fledgling aspect of ear biology, the breadth of miRNA expression and functional requirement for ear development are already sounding off.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.