ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Deafness in TRbeta mutants is caused by malformation of the tectorial membrane.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.Thyroid : official journal of the American Thyroid Association · 2014Guideline
- Insights on the role of thyroid hormone transport in neurosensory organs and implication for the Allan-Herndon-Dudley syndrome.European thyroid journal · 2024Review
- Article
- The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring.International archives of otorhinolaryngology · 2022Article
- Gαi Proteins are Indispensable for Hearing.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Article
- Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.Cell reports · 2017Article
- Micro-optical coherence tomography of the mammalian cochlea.Scientific reports · 2016Article
- Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1.Endocrinology · 2015Article
- Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life.Cell and tissue research · 2015Review
- Deciphering direct and indirect influence of thyroid hormone with mouse genetics.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Conditional gene expression in the mouse inner ear using Cre-loxP.Journal of the Association for Research in Otolaryngology : JARO · 2012Review
- Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis?Frontiers in neuroanatomy · 2012Article
- Thyroid hormone action in cerebellum and cerebral cortex development.Journal of thyroid research · 2011Article
- Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011Article
- Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation.Disease models & mechanismsArticle
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 7 countries.
Funding
Abstract
Thyroid hormone receptor beta (TRbeta) dysfunction leads to deafness in humans and mice. Deafness in TRbeta(-/-) mutant mice has been attributed to TRbeta-mediated control of voltage- and Ca(2+)-activated K(+) (BK) channel expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKalpha(-/-) mutants contradicts this hypothesis. Here, we show that mice with hair cell-specific deletion of TRbeta after postnatal day 11 (P11) have a delay in BKalpha expression but normal hearing, indicating that the origin of hearing loss in TRbeta(-/-) mutant mice manifested before P11. Analyzing the phenotype of IHCs in constitutive TRbeta(-/-) mice, we found normal Ca(2+) current amplitudes, exocytosis, and shape of compound action potential waveforms. In contrast, reduced distortion product otoacoustic emissions and cochlear microphonics associated with an abnormal structure of the tectorial membrane and enhanced tectorin levels suggest that disturbed mechanical performance is the primary cause of deafness resulting from TRbeta deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.