ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Spatiotemporal molecular dynamics of the developing human thalamus.Science (New York, N.Y.) · 2023Article
- Generation of ventralized human thalamic organoids with thalamic reticular nucleus.Cell stem cell · 2023Article
- Review
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.Cell reports · 2022Article
- Genesis of the Master Circadian Pacemaker in Mice.Frontiers in neuroscience · 2021Review
- The Ciliopathy GeneThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Taiji: System-level identification of key transcription factors reveals transcriptional waves in mouse embryonic development.Science advances · 2019Article
- Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer.Brain structure & function · 2019Article
- Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh.Molecular neurobiology · 2017Article
- Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus.Nature neuroscience · 2017Article
- Differential Cellular Responses to Hedgehog Signalling in Vertebrates-What is the Role of Competence?Journal of developmental biology · 2016Review
- An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center.Journal of developmental biology · 2016Review
- Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus.Development (Cambridge, England) · 2016Article
- Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade.PloS one · 2016Article
- ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm.Development (Cambridge, England) · 2015Article
- Prepatterning and patterning of the thalamus along embryonic development of Xenopus laevis.Frontiers in neuroanatomy · 2015Article
- LIM homeobox protein 5 (Lhx5) is essential for mamillary body development.Frontiers in neuroanatomy · 2015Article
- Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus.Frontiers in neuroanatomy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The specification of the intricate neuronal assemblies that characterize the forebrain is not well understood. The ventral spinal cord is specified through a concentration gradient of Sonic hedgehog (Shh) protein secreted by the notochord. Shh is expressed also in the forebrain neuroepithelium (neural Shh) and the underlying notochord and prechordal plate. Neural Shh is essential for the development of the prethalamus (ventral thalamus), but its effects on the thalamus (dorsal thalamus) are still unclear. We hypothesized that neural Shh would act on a previously regionalized dorsal diencephalic region to promote the emergence of specific thalamic nuclear and histological traits. To find out, we generated a conditional mouse mutant line specifically lacking Shh expression in the diencephalic neuroepithelium. We show that the transcription factor Gbx2, required for thalamic development downstream Shh, is expressed in our mutant in a restricted thalamic region and is necessary and sufficient for the differentiation of the medial and intralaminar thalamic nuclei. In the rest of the thalamus, neural Shh is required to promote neuronal aggregation into nuclei as well as axonal extension. In this way, the individual thalamic nuclei show differential dependence on Shh, Gbx2, or both for their differentiation. Additionally, Gbx2 is required for the survival of thalamic neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.