ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Diacylglycerol Activates theInternational journal of molecular sciences · 2023Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Membrane Stretch Gates NMDA Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Role of Membrane Lipids in Light-Activation ofBiomolecules · 2022Review
- PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.PLoS genetics · 2020Article
- Remembering Mechanosensitivity of NMDA Receptors.Frontiers in cellular neuroscience · 2019Review
- Article
- Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction.NPJ schizophrenia · 2017Article
- Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels.Frontiers in physiology · 2017Review
- The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go.Scientific reports · 2016Article
- Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.Neuropharmacology · 2014Article
- Diacylglycerol activates the light-dependent channel TRP in the photosensitive microvilli of Drosophila melanogaster photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors.Journal of neurophysiology · 2013Article
- Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Signal-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate without activation of phospholipase C: implications on gating of Drosophila TRPL (transient receptor potential-like) channel.The Journal of biological chemistry · 2012Article
- Relief of Mg²⁺-dependent inhibition of TRPM1 by PKCα at the rod bipolar cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The history of the Drosophila TRP channel: the birth of a new channel superfamily.Journal of neurogenetics · 2010Review
- Intrinsically photosensitive retinal ganglion cells.Physiological reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Open channel block is a process in which ions bound to the inside of a channel pore block the flow of ions through that channel. Repulsion of the blocking ions by depolarization is a known mechanism of open channel block removal. For the NMDA channel, this mechanism is necessary for channel activation and is involved in neuronal plasticity. Several types of transient receptor potential (TRP) channels, including the Drosophila TRP and TRP-like (TRPL) channels, also exhibit open channel block. Therefore, removal of open channel block is necessary for the production of the physiological response to light. Because there is no membrane depolarization before the light response develops, it is not clear how the open channel block is removed, an essential step for the production of a robust light response under physiological conditions. Here we present a novel mechanism to alleviate open channel block in the absence of depolarization by membrane lipid modulations. The results of this study show open channel block removal by membrane lipid modulations in both TRPL and NMDA channels of the photoreceptor cells and CA1 hippocampal neurons, respectively. Removal of open channel block is characterized by an increase in the passage-rate of the blocking cations through the channel pore. We propose that the profound effect of membrane lipid modulations on open channel block alleviation, allows the productions of a robust current in response to light in the absence of depolarization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.