ArticleJournal of clinical microbiology2009
Genotyping of clinical varicella-zoster virus isolates collected in China.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China.Virology journal · 2025Article
- Genotype of Varicella-zoster virus isolated in Jiangsu, China.Virology journal · 2024Article
- Genomic sequencing revealed recombination event between clade 1 and clade 2 occurs in circulating varicella-zoster virus in China.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing.Open medicine (Warsaw, Poland) · 2023Article
- Meningitis/meningoencephalitis caused by varicella zoster virus reactivation: a retrospective single-center case series study.American journal of translational research · 2022Article
- Differentiation between wild-type and vaccines strains of varicella zoster virus (VZV) based on four single nucleotide polymorphisms.Epidemiology and infection · 2017Article
- Characterization and phylogenetic analysis of Varicella-zoster virus strains isolated from Korean patients.Journal of microbiology (Seoul, Korea) · 2017Article
- Genetic analysis of varicella-zoster virus in the aqueous humor in uveitis with severe hyphema.BMC infectious diseases · 2017Article
- Nationwide distribution of varicella-zoster virus clades in China.BMC infectious diseases · 2016Article
- Genotyping of clinical varicella-zoster virus isolates collected from Yunnan in Southwestern China.Biomedical reports · 2016Article
- Genetic analysis of clinical VZV isolates collected in China reveals a more homologous profile.BioMed research international · 2013Article
- Sequencing and characterization of Varicella-zoster virus vaccine strain SuduVax.Virology journal · 2011Article
- Genotype of varicella-zoster virus isolates in South Korea.Journal of clinical microbiology · 2011Article
- Article
- Simultaneous cocirculation of both European varicella-zoster virus genotypes (E1 and E2) in Mexico city.Journal of clinical microbiology · 2010Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varicella-zoster virus (VZV) is genetically stable; and various schemes for the genotyping of VZV based on restriction fragment length polymorphisms (RFLPs), PCR, and sequencing have been developed. At least three major genotypes have been recognized among VZV isolates or clinical samples from different locations around the world; however, few data were available for viral isolates from China. In the current study, a collection of 19 VZV isolates from patients with zoster or varicella in the middle eastern region of China was examined for genetic variations. RFLP analysis of DNA fragments of open reading frames (ORFs) 38, 54, and 62 showed that all 19 isolates were PstI and BglI positive and SmaI negative, and this may represent the major restriction pattern of wild-type VZV strains in China. Further analysis of the R5 variable-repeat region in those strains revealed that 9 (47.4%) were type R5A, while the remaining 10 strains (52.6%) were type R5B. On the basis of the sequencing data for ORFs 1, 21, 22, and 54, all 19 Chinese strains could be grouped into genotype J or J1. A novel in-frame 3-nucleotide insertion (CGG) in ORF1 was found in 4 (21%) of the 19 isolates. Additionally three new nucleotide substitutions were detected in two of the isolates. A varicella isolate from the United States, strain MLS, was included in this study as a control for American wild-type VZV, and was found to be type M1, which represents one of the minor genotypes in North America.
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