ArticleJournal of neurophysiology2009
Differential metabotropic glutamate receptor expression and modulation in two neocortical inhibitory networks.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex.Frontiers in synaptic neuroscience · 2026Article
- Loss of mGluMolecular psychiatry · 2024Article
- Multiple layers of diversity govern the cell type specificity of GABAergic input received by mouse subicular pyramidal neurons.The Journal of physiology · 2024Article
- Review
- Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons.Frontiers in psychiatry · 2022Article
- S100A10 and its binding partners in depression and antidepressant actions.Frontiers in molecular neuroscience · 2022Review
- A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons.Cerebral cortex communications · 2020Article
- Cholinergic Neurons of the Medial Septum Are Crucial for Sensorimotor Gating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- APP Causes Hyperexcitability in Fragile X Mice.Frontiers in molecular neuroscience · 2016Article
- Alteration by p11 of mGluR5 localization regulates depression-like behaviors.Molecular psychiatry · 2015Article
- Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.Neuropharmacology · 2013Article
- mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion.PloS one · 2013Article
- Article
- Dendritic Signaling in Inhibitory Interneurons: Local Tuning via Group I Metabotropic Glutamate Receptors.Frontiers in physiology · 2012Article
- Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.Journal of neurophysiology · 2011Article
- Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.Developmental neurobiology · 2011Article
- Fragile X syndrome: the GABAergic system and circuit dysfunction.Developmental neuroscience · 2011Review
- NMDA receptor hypofunction phase couples independent γ-oscillations in the rat visual cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- θ burst and conventional low-frequency rTMS differentially affect GABAergic neurotransmission in the rat cortex.Experimental brain research · 2009Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Taking advantage of transgenic mice with genetically labeled GABA-releasing interneurons, we examined the cell-specific patterns of mGluR expression in two broadly defined subtypes of inhibitory interneurons in layer IV of somatosensory cortex. Electrophysiological recording combined with application of specific agonists for specific mGluRs demonstrated different effects of mGluR activation in fast-spiking (FS) versus regular spiking nonpyramidal (RSNP) interneurons. Whereas activation of group I, II, and III mGluRs inhibited excitatory synaptic transmission in RSNP neurons predominantly via postsynaptic mechanisms, group I mGluR activation depolarized FS but not RSNP interneurons. Immunoreactivities of mGluR1, mGluR5, mGluR2/3, and mGluR8 exhibited different cellular expression patterns in the two groups of neurons that were not entirely consistent with physiological and pharmacological experiments. Taken together, our data indicate cell and circuit-specific roles for mGluRs in modulating inhibitory circuits in the somatosensory cortex. These results help to reinforce the concept that RSNP and FS cells represent morphologically, physiologically, and functionally distinct groups of interneurons. The results reported here help to increase our understanding of the roles of mGluRs in endogenous glutamatergic-induced plasticity of interneuronal networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.