ArticleJournal of neurophysiology2009
Evidence that exocytosis is driven by calcium entry through multiple calcium channels in goldfish retinal bipolar cells.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Quantitative Proteomics Identifies Potential Molecular Adaptations in Mouse Models of Congenital Stationary Night Blindness Type 2.Molecular & cellular proteomics : MCP · 2025Article
- Article
- The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease.International journal of molecular sciences · 2024Review
- Stationary CaBiophysical journal · 2021Article
- Direct Observation of Vesicle Transport on the Synaptic Ribbon Provides Evidence That Vesicles Are Mobilized and Prepared Rapidly for Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Efficient Approximations for Stationary Single-Channel CaBiophysical journal · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Extension of Rapid Buffering Approximation to CaBiophysical journal · 2018Article
- The Coupling between CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Padé Approximation of a Stationary Single-Channel CaBiophysical journal · 2016Article
- Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.Cell reports · 2016Article
- Weak endogenous Ca2+ buffering supports sustained synaptic transmission by distinct mechanisms in rod and cone photoreceptors in salamander retina.Physiological reports · 2015Article
- A synaptic mechanism for temporal filtering of visual signals.PLoS biology · 2014Article
- Single Ca2+ channels and exocytosis at sensory synapses.The Journal of physiology · 2013Review
- Amperometric resolution of a prespike stammer and evoked phases of fast release from retinal bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Lateral mobility of L-type calcium channels in synaptic terminals of retinal bipolar cells.Molecular vision · 2013Article
- Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.Journal of neurophysiology · 2011Article
- Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development of new peptide-based tools for studying synaptic ribbon function.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ribbon-containing neurons represent a subset of neural cells that undergo graded membrane depolarizations rather than Na(+)-channel evoked action potentials. Bipolar cells of the retina are one type of ribbon-containing neuron and extensive research has demonstrated kinetically distinct pools of vesicles that are released and replenished in a calcium-dependent manner. In this study, we look at the properties of the fastest pool of releasable vesicles in these cells, often referred to as the immediately releasable pool (IRP), to investigate the relationships between vesicle release and calcium channels in these terminals. Using whole cell capacitance measurements, we monitored exocytosis in response to different magnitude and duration depolarizations, with emphasis on physiologically relevant step depolarizations. We find that release rate of the IRP increases superlinearly with membrane potential and that the IRP is sensitive to elevated EGTA concentrations in a membrane-potential-dependent manner across the physiological range of membrane potentials. Our results are best explained by a model in which multiple Ca(2+) channels act in concert to drive exocytosis of a single synaptic vesicle. Pooling calcium entering through many calcium channels may be important for reducing stochastic noise in neurotransmitter release associated with the opening of individual calcium channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.