ArticleMolecular biology of the cell2009
Syndapin promotes formation of a postsynaptic membrane system in Drosophila.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Distinct Bin/Amphiphysin/Rvs (BAR) family proteins may assemble on the same tubule to regulate membrane organizationHeliyon · 2024Article
- PACSIN proteins in vivo: Roles in development and physiology.Acta physiologica (Oxford, England) · 2022Review
- Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei.PLoS genetics · 2021Article
- Synapse development and maturation at the drosophila neuromuscular junction.Neural development · 2020Review
- The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.Nature communications · 2020Article
- RNAi Screen inG3 (Bethesda, Md.) · 2019Article
- Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila.PloS one · 2019Article
- Filamin, a synaptic organizer ineLife · 2016Article
- Syndapin/SDPN-1 is required for endocytic recycling and endosomal actin association in the C. elegans intestine.Molecular biology of the cell · 2016Article
- Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila embryo.Molecular biology of the cell · 2016Article
- Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation.Cell reports · 2015Article
- Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets.Biology direct · 2015Article
- The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function.Molecular biology of the cell · 2015Article
- Article
- Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction.Developmental neurobiology · 2013Article
- Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck.Molecular biology of the cell · 2013Article
- Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.The EMBO journal · 2013Article
- Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast.Current biology : CB · 2011Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Syndapins belong to the F-BAR domain protein family whose predicted functions in membrane tubulation remain poorly studied in vivo. At Drosophila neuromuscular junctions, syndapin is associated predominantly with a tubulolamellar postsynaptic membrane system known as the subsynaptic reticulum (SSR). We show that syndapin overexpression greatly expands this postsynaptic membrane system. Syndapin can expand the SSR in the absence of dPAK and Dlg, two known regulators of SSR development. Syndapin's N-terminal F-BAR domain, required for membrane tubulation in cultured cells, is required for SSR expansion. Consistent with a model in which syndapin acts directly on postsynaptic membrane, SSR expansion requires conserved residues essential for membrane binding in vitro. However, syndapin's Src homology (SH) 3 domain, which negatively regulates membrane tubulation in cultured cells, is required for synaptic targeting and strong SSR induction. Our observations advance knowledge of syndapin protein function by 1) demonstrating the in vivo relevance of membrane remodeling mechanisms suggested by previous in vitro and structural analyses, 2) showing that SH3 domains are necessary for membrane expansion observed in vivo, and 3) confirming that F-BAR proteins control complex membrane structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.