ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2009
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Genomic mapping reveals cisplatin disruption of protein phosphorylation signalling genome-wide.Metallomics : integrated biometal science · 2026Article
- Understanding Abnormal c-JNK/p38MAPK Signaling Overactivation Involved in the Progression of Multiple Sclerosis: Possible Therapeutic Targets and Impact on Neurodegenerative Diseases.Neurotoxicity research · 2021Review
- Approximate inference of gene regulatory network models from RNA-Seq time series data.BMC bioinformatics · 2018Article
- Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes.Stem cell research & therapy · 2017Article
- Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenic differentiation.Skeletal muscle · 2015Article
- Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation.Nature communications · 2014Article
- A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.Frontiers in neuroscience · 2014Article
- Article
- CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling.PloS one · 2014Article
- SPAG9 is overexpressed in human astrocytoma and promotes cell proliferation and invasion.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells.Biochimica et biophysica acta · 2013Article
- TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.The Journal of biological chemistry · 2012Article
- How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?Immunological reviews · 2011Review
- Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells.Stem cells (Dayton, Ohio) · 2011Article
- Cdo interacts with APPL1 and activates Akt in myoblast differentiation.Molecular biology of the cell · 2010Article
- Abl promotes cadherin-dependent adhesion and signaling in myoblasts.Cell cycle (Georgetown, Tex.) · 2010Article
- N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.Molecular and cellular biology · 2009Article
- Recruiting endogenous stem cells: a novel therapeutic approach for erectile dysfunction.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Neural basic helix-loop-helix transcription factors (bHLHs) control many aspects of neurogenesis, such as proliferation, fate determination, and differentiation. We have previously shown that the promyogenic cell surface receptor Cdo modulates the Cdc42 and p38 mitogen-activated protein kinase (MAPK) pathways via a direct association with two scaffold-type proteins, JLP and Bnip-2, to regulate activities of myogenic bHLH factors and myogenic differentiation. We report here that Cdo uses similar regulatory mechanisms to promote neuronal differentiation. Expression of JLP, a scaffold protein for p38MAPK, and Bnip-2, a regulator of Cdc42, is increased during differentiation of C17.2 neural precursor cells and P19 embryonal carcinoma cells. These molecules regulate Cdc42 and p38MAPK activities, which increase in a Cdo-dependent manner during neuronal differentiation of C17.2 cells and retinoic acid-treated P19 cells. Furthermore, enhancement or reduction of Cdc42 and p38MAPK activities enhances or reduces, respectively, neuronal differentiation of these cell lines. Cdc42 and p38MAPK activities also promote heterodimerization of neurogenin1 and E47, suggesting that one way they promote neurogenesis is via regulation of neural bHLH factor activities. These results imply that a conserved intracellular signaling mechanism initiated by Cdo regulates the activities of tissue-specific bHLH factors and therefore functions as a key regulator of differentiation of several different cell lineages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.