ArticleDevelopment (Cambridge, England)2009
Crossveinless and the TGFbeta pathway regulate fiber number in the Drosophila adult jump muscle.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- TheiScience · 2026Article
- Enhanced expression of the myogenic factor Myocyte enhancer factor-2 in imaginal disc myoblasts activates a partial, but incomplete, muscle development program.Developmental biology · 2024Article
- An insight on Drosophila myogenesis and its assessment techniques.Molecular biology reports · 2020Review
- Absence of the Drosophila jump muscle actin Act79B is compensated by up-regulation of Act88F.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- An undergraduate laboratory class using CRISPR/Cas9 technology to mutate drosophila genes.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2016Article
- Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila.The Journal of cell biology · 2014Article
- The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development.Genetics · 2013Article
- Extradenticle and homothorax control adult muscle fiber identity in Drosophila.Developmental cell · 2012Article
- Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing.Development (Cambridge, England) · 2012Article
- Differential requirements for Myocyte Enhancer Factor-2 during adult myogenesis in Drosophila.Developmental biology · 2012Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Skeletal muscles are readily characterized by their location within the body and by the number and composition of their constituent muscle fibers. Here, we characterize a mutation that causes a severe reduction in the number of fibers comprising the tergal depressor of the trochanter muscle (TDT, or jump muscle), which functions in the escape response of the Drosophila adult. The wild-type TDT comprises over 20 large muscle fibers and four small fibers. In crossveinless (cv) mutants, the number of large fibers is reduced by 50%, and the number of small fibers is also occasionally reduced. This reduction in fiber number arises from a reduction in the number of founder cells contributing to the TDT at the early pupal stage. Given the role of cv in TGFbeta signaling, we determined whether this pathway directly impacts TDT development. Indeed, gain- and loss-of-function manipulations in the TGFbeta pathway resulted in dramatic increases and decreases, respectively, in TDT fiber number. By identifying the origins of the TDT muscle, from founder cells specified in the mesothoracic leg imaginal disc, we also demonstrate that the TGFbeta pathway directly impacts the specification of founder cells for the jump muscle. Our studies define a new role for the TGFbeta pathway in the control of specific skeletal muscle characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.