Evidence map›Paper›PMID 19244270›Full record

ReviewBritish journal of sports medicine2009

Mechanotherapy: how physical therapists' prescription of exercise promotes tissue repair.

K M Khan, A Scott

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of sports medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04320355 (Exploring the Effects of Soft Tissue Manual Therapy on the Viscoelastic Properties, Pressure Sensitivity and Touch Sensitivity of the Caesarean Section Scar), which is not on this map. Cited by 135 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 8 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04320355 nacompletednot on this mapstarted 2020, after this paper: background citation

Exploring the Effects of Soft Tissue Manual Therapy on the Viscoelastic Properties, Pressure Sensitivity and Touch Sensitivity of the Caesarean Section Scar

TypeinterventionalSponsorUniversité de SherbrookeRan2020 to 2020Enrolled51ConditionsCesarean Section ComplicationsArmsSoft tissue manual therapy
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 8 syntheses or guidelines pooled it, 412 citations in OpenAlex.

  1. Pooled it
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  8. ESWT for tendinopathy: technology and clinical implications.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013
    Pooled it
  9. Trial
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  12. Instrumented assisted soft tissue mobilizationWorld journal of orthopedics · 2023
    Trial
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  16. Does an unloader brace reduce knee loading in normally aligned knees?Clinical orthopaedics and related research · 2014
    Trial
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  18. Article
  19. Review
  20. Review

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

K M KhanCentre for Hip Health and Mobility and Department of Family Practice, University of British Columbia, Vancouver, Canada. karim.khan@ubc.ca
A Scott
University of British Columbia · CA

Funding

CIHR 78141-1
6 · The paper itself

Abstract

Mechanotransduction is the physiological process where cells sense and respond to mechanical loads. This paper reclaims the term "mechanotherapy" and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and bone. The purpose of this short article is to answer a frequently asked question "How precisely does exercise promote tissue healing?" This is a fundamental question for clinicians who prescribe exercise for tendinopathies, muscle tears, non-inflammatory arthropathies and even controlled loading after fractures. High-quality randomised controlled trials and systematic reviews show that various forms of exercise or movement prescription benefit patients with a wide range of musculoskeletal problems.1(-)4 But what happens at the tissue level to promote repair and remodelling of tendon, muscle, articular cartilage and bone? The one-word answer is "mechanotransduction", but rather than finishing there and limiting this paper to 95 words, we provide a short illustrated introduction to this remarkable, ubiquitous, non-neural, physiological process. We also re-introduce the term "mechanotherapy" to distinguish therapeutics (exercise prescription specifically to treat injuries) from the homeostatic role of mechanotransduction. Strictly speaking, mechanotransduction maintains normal musculoskeletal structures in the absence of injury. After first outlining the process of mechanotransduction, we provide well-known clinical therapeutic examples of mechanotherapy-turning movement into tissue healing.

Indexed as

Exercise TherapyHumansMechanotransduction, CellularMusculoskeletal SystemWound Healing

Identifiers

PMID19244270
PMCPMC2662433
OpenAlexW2150055810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.