ArticleEuropean journal of cancer (Oxford, England : 1990)2009
Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland.
Article in European journal of cancer (Oxford, England : 1990), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Gene-diet interactions in gastric cancer risk: a systematic review.World journal of gastroenterology · 2014Pooled it
- Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants.The American journal of clinical nutrition · 2010Pooled it
- Novel susceptibility gene SLC23A2 functions via PI3K-AKT-mTOR pathway in etiology of non-syndromic cleft palate.Journal of human genetics · 2025Observational
- Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer.Antioxidants (Basel, Switzerland) · 2023Review
- Transcriptional and genetic alterations of cuproptosis-related genes correlated to malignancy and immune-infiltrate of esophageal carcinoma.Cell death discovery · 2022Article
- A guide to plasma membrane solute carrier proteins.The FEBS journal · 2021Review
- Review
- Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.Nutrients · 2021Review
- Mutation SVCT2 promotes cell proliferation, invasion and migration in colorectal cancer.Journal of Cancer · 2021Article
- Vitamin C Transporters and Their Implications in Carcinogenesis.Nutrients · 2020Review
- Pathways of Gastric Carcinogenesis,International journal of molecular sciences · 2020Review
- Targeting cancer vulnerabilities with high-dose vitamin C.Nature reviews. Cancer · 2019Review
- Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2.NPJ precision oncology · 2018Article
- Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation.Theranostics · 2018Article
- ROS-modulated therapeutic approaches in cancer treatment.Journal of cancer research and clinical oncology · 2017Review
- Fruit and vegetable intake and vitamin C transporter gene (SLC23A2) polymorphisms in chronic lymphocytic leukaemia.European journal of nutrition · 2017Article
- Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge.Frontiers in oncology · 2017Review
- Different Pathophysiology of Gastritis in East and West? A Western Perspective.Inflammatory intestinal diseases · 2016Review
- The epigenetic role of vitamin C in health and disease.Cellular and molecular life sciences : CMLS · 2016Review
- Genetic Variation in Human Vitamin C Transporter Genes in Common Complex Diseases.Advances in nutrition (Bethesda, Md.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Higher ascorbic acid consumption is associated with a reduced risk of gastric cancer in numerous epidemiologic studies. We investigated whether single nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2--genes that encode key ascorbic acid transport proteins--affect gastric cancer risk in 279 incident cases and 414 age- and gender-matched controls drawn from a population-based case-control study in Poland. Compared to subjects who were homozygous for the common G allele of the SLC23A2 SNP rs12479919, carriers of the AA genotype had a 41% lower risk of gastric cancer [odds ratio (OR)=0.59, 95% confidence interval (CI): 0.36-0.95; P trend=0.06]. A haplotype that contained the common allele of the rs6139591, rs2681116 and rs14147458 SNPs in SLC23A2 was also significantly inversely associated with gastric malignancy. No other polymorphisms in either gene were related to risk, and there was no effect modification by ascorbic acid intake. These findings suggest that genetic variation in SLC23A2 impacts gastric cancer risk, although confirmation in other studies is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.