ArticleProceedings of the National Academy of Sciences of the United States of America1991
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.Biochemistry · 2015Article
- Mammalian iron-sulphur proteins: novel insights into biogenesis and function.Nature reviews. Molecular cell biology · 2015Review
- Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells.The EMBO journal · 2000Article
- The molecular basis for the role of zinc in developmental biology.Molecular and cellular biochemistry · 1998Review
- Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
- ZmHox: a novel class of maize homeobox genes.Plant molecular biology · 1996Article
- Islet expression of Rhombotin and Isl-1 suggests cell type specific exposure of LIM-domain epitopes.Endocrine · 1995Article
- Purification and characterization of thyroid transcription factor 2.The Biochemical journal · 1994Article
- Pancreatic beta cells express a diverse set of homeobox genes.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains.Nucleic acids research · 1994Article
- Activation of the glycoprotein hormone alpha-subunit promoter by a LIM-homeodomain transcription factor.Molecular and cellular biology · 1994Article
- Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton.The Journal of cell biology · 1994Article
- Variant-specific surface proteins of Giardia lamblia are zinc-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The LIM motif defines a specific zinc-binding protein domain.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Identification and preliminary characterization of a protein motif related to the zinc finger.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The patB gene product, required for growth of the cyanobacterium Anabaena sp. strain PCC 7120 under nitrogen-limiting conditions, contains ferredoxin and helix-turn-helix domains.Journal of bacteriology · 1993Article
- Regulation of cysteine-rich intestinal protein by dexamethasone in the neonatal rat.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
The cysteine-rich LIM motif is highly conserved between invertebrates and mammals. This motif shows similarity both to proteins that bind zinc and to ferredoxins, which contain iron-sulfur clusters. Two tandem copies of the LIM motif are found in a number of presumptive transcription factors, including the protein product of the Caenorhabditis elegans cell-lineage gene lin-11. To investigate the possible metal-binding properties of the LIM region of the lin-11 protein, we expressed and purified a 151-amino acid peptide containing the tandem LIM motifs. The purified peptide binds both zinc (two atoms per protein molecule) and iron (as a redox-active iron-sulfur cluster, with four atoms of iron and four atoms of inorganic sulfide per protein molecule). These observations suggest that the LIM motif is a metallodomain that might function in a redox-sensitive regulation of transcription.
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