Trial reportFertility and sterility2010
Short-term hormone treatment modulates emotion response circuitry in postmenopausal women.
Trial report in Fertility and sterility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- Brain functional changes in perimenopausal women: an amplitude of low-frequency fluctuation study.Menopause (New York, N.Y.) · 2021Article
- Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress-Mediated Anxiety and Depression.BioMed research international · 2020Article
- Associations Between Natural Physiological and Supraphysiological Estradiol Levels and Stress Perception.Frontiers in psychology · 2019Article
- Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females.Brain sciences · 2018Article
- Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity.Scientific reports · 2017Article
- Effect of Cynomorium total flavone on depression model of perimenopausal rat.Saudi journal of biological sciences · 2017Article
- Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle.Psychoneuroendocrinology · 2015Article
- Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study.PloS one · 2015Article
- Enhanced Neuroactivation during Working Memory Task in Postmenopausal Women Receiving Hormone Therapy: A Coordinate-Based Meta-Analysis.Frontiers in human neuroscience · 2015Review
- Functional and molecular neuroimaging of menopause and hormone replacement therapy.Frontiers in neuroscience · 2014Review
- Postmenopausal hormone use impact on emotion processing circuitry.Behavioural brain research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo study the effects of combination hormone therapy (HT) on emotional processing in postmenopausal women with use of functional neuroimaging.
designA randomized, double-blind, placebo-controlled crossover study was performed.
settingA tertiary care university medical center. PARTICIPANT(S): Ten healthy postmenopausal women (mean age 56.9 years, SD = 1.4 years) were recruited. INTERVENTION(S): Women were assigned randomly to the order they received combined HT, 5 microg ethinyl E(2) and 1 mg norethindrone acetate, and placebo. Volunteers received HT or placebo for 4 weeks, followed by a 1-month washout period, and then received the other treatment for 4 weeks. Subjects participated in a functional magnetic resonance imaging emotional processing task, where they were asked to rate emotional pictures as positive, negative, or neutral. MAIN OUTCOME MEASURE(S): Brain activation patterns were compared between HT and placebo conditions within subjects. RESULT(S): During negative emotional presentations, after subtracting the effect of neutral images, areas of significant differences between HT and placebo conditions were identified in the orbital, frontal, cingulate, and occipital cortices. During positive emotional image presentation there were significant differences between placebo and HT conditions within the medial frontal cortex.
conclusionsShort-term menopausal treatment with combination HT affects regional brain activity within areas implicated in emotional processing.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.