ArticleCardiovascular diabetology2009
Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects.
Article in Cardiovascular diabetology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.PloS one · 2013Pooled it
- Alpha-adducin Gly460Trp polymorphism and hypertension risk: a meta-analysis of 22 studies including 14303 cases and 15961 controls.PloS one · 2010Pooled it
- Lack of association between alpha-adducin G460W polymorphism and hypertension: evidence from a case-control study and a meta-analysis.Journal of human hypertension · 2010Pooled it
- Model of genetic and environmental factors associated with type 2 diabetes mellitus in a Chinese Han population.BMC public health · 2020Article
- Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.Endocrine reviews · 2019Review
- Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population.Lipids in health and disease · 2018Article
- Association betweenInternational journal of molecular and cellular medicine · 2017Article
- Association of Mbo I-RFLP at the Renin Locus (rs2368564) with Essential Hypertension.Indian journal of clinical biochemistry : IJCB · 2016Article
- Study of Common Genetic Variant S447X in Lipoprotein Lipase and Its Association with Lipids and Lipoproteins in Type 2 Diabetic Patients.Indian journal of clinical biochemistry : IJCB · 2016Article
- Higher blood aldosterone level in metabolic syndrome is independently related to adiposity and fasting plasma glucose.Cardiovascular diabetology · 2015Article
- Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years.PloS one · 2015Article
- Association of Angiotensin Converting Enzyme Insertion-Deletion Polymorphism with Hypertension in Emiratis with Type 2 Diabetes Mellitus and Its Interaction with Obesity Status.Disease markers · 2015Article
- Gender specific association of RAS gene polymorphism with essential hypertension: a case-control study.BioMed research international · 2014Article
- Renin gene polymorphisms in bangladeshi hypertensive population.Journal of genomics · 2014Article
- Genetic contribution and associated pathophysiology in end-stage renal disease.The application of clinical genetics · 2010Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundThe renin-angiotensin aldosterone system (RAAS) plays an important role in regulating the blood pressure and the genetic polymorphisms of RAAS genes has been extensively studied in relation to the cardiovascular diseases in various populations with conflicting results. The aim of this study was to determine the association of five genetic polymorphisms (A6G and A20C of angiotensinogen (AGT), MboI of renin, Gly460Trp of aldosterone synthase and Lys173Arg of adducin) of RAAS genes in Malaysian essential hypertensive and type 2 diabetic subjects.
methodsRAAS gene polymorphisms were determined using mutagenically separated PCR and PCR-RFLP method in a total of 270 subjects consisting of 70 hypertensive subjects without type 2 diabetes mellitus (T2DM), 60 T2DM, 65 hypertensive subjects with T2DM and 75 control subjects.
resultsThere was significant difference found in age, body mass index, systolic/diastolic blood pressure, fasting plasma glucose and high density lipoprotein cholesterol levels between the hypertensive subjects with or without T2DM and control subjects. No statistically significant differences between groups were found in the allele frequency and genotype distribution for A20C variant of AGT gene, MboI of renin, Gly460Trp of aldosterone and Lys173Arg of adducin (p > 0.05). However, the results for A6G of AGT gene revealed significant differences in allele and genotype frequencies in essential hypertension with or without T2DM (p < 0.001).
conclusionAmong the five polymorphisms of RAAS genes only A6G variant of AGT gene was significantly associated in Malaysian essential hypertensive and type 2 diabetic subjects. Therefore, A6G polymorphism of the AGT gene could be a potential genetic marker for increased susceptibility to essential hypertension with or without T2DMin Malaysian subjects.
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