ArticleBMC microbiology2009
Quelling targets the rDNA locus and functions in rDNA copy number control.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Functions of RNAi Pathways in Ribosomal RNA Regulation.Non-coding RNA · 2024Review
- piRNA generation is associated with the pioneer round of translation in stem cells.Nucleic acids research · 2024Article
- An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans.Developmental cell · 2021Article
- Conserved chromosomal functions of RNA interference.Nature reviews. Genetics · 2020Review
- Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing inInternational journal of molecular sciences · 2020Article
- RNA interference is essential for cellular quiescence.Science (New York, N.Y.) · 2016Article
- Mechanism of siRNA production from repetitive DNA.Genes & development · 2015Article
- Article
- Histone H3K56 acetylation is required for quelling-induced small RNA production through its role in homologous recombination.The Journal of biological chemistry · 2014Article
- Article
- Novel proteins required for meiotic silencing by unpaired DNA and siRNA generation in Neurospora crassa.Genetics · 2013Article
- Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway.Genes & development · 2013Article
- Hairpin dsRNA does not trigger RNA interference in Candida albicans cells.Yeast (Chichester, England) · 2011Article
- RNA interference pathways in filamentous fungi.Cellular and molecular life sciences : CMLS · 2010Review
- QIP, a protein that converts duplex siRNA into single strands, is required for meiotic silencing by unpaired DNA.Genetics · 2010Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRNA silencing occurs in a broad range of organisms. Although its ancestral function is probably related to the genome defense mechanism against repetitive selfish elements, it has been found that RNA silencing regulates different cellular processes such as gene expression and chromosomal segregation. In Neurospora crassa, a RNA silencing mechanism, called quelling, acts to repress the expression of transgenes and transposons, but until now no other cellular functions have been shown to be regulated by this mechanism.
resultsHere, we detected by northern blotting endogenous short interfering RNA (siRNAs) from the repetitive ribosomal DNA locus (rDNA) that are loaded onto the argonaute protein QDE-2. Moreover, we found a bidirectional transcription that can generate double strand RNA (dsRNA) molecules. Interestingly, quelling mutants have a reduced rDNA gene copy number.
conclusionOur finding could suggest a new biological function for RNA silencing in the maintenance of the integrity and stability of the Neurospora rDNA locus.
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