ArticleProceedings of the National Academy of Sciences of the United States of America1991
Isolation of a cellular protein that binds to the human immunodeficiency virus Tat protein and can potentiate transactivation of the viral promoter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- p32 is a negative regulator of p53 tetramerization and transactivation.Molecular oncology · 2019Article
- The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.Oncogene · 2007Article
- In vitro and in vivo interactions between the hepatitis B virus protein P22 and the cellular protein gC1qR.Journal of virology · 2003Article
- Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.Journal of virology · 1998Article
- The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.Genes & development · 1997Article
- The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.Molecular and cellular biology · 1997Article
- Cooperation between herpes simplex virus type 1-encoded ICP0 and Tat to support transcription of human immunodeficiency virus type 1 long terminal repeat in vivo can occur in the absence of the TAR binding site.Journal of virology · 1996Article
- Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors.Gene expression · 1996Article
- A human chromosome 12-associated 83-kilodalton cellular protein specifically binds to the loop region of human immunodeficiency virus type 1 trans-activation response element RNA.Journal of virology · 1995Article
- Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.Journal of virology · 1995Article
- In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP.Journal of virology · 1995Article
- Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain.Journal of virology · 1995Article
- Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor.Journal of virology · 1995Article
- Novel mechanism and factor for regulation by HIV-1 Tat.The EMBO journal · 1995Article
- Transcriptional activation in vitro by the human immunodeficiency virus type 1 Tat protein: evidence for specific interaction with a coactivator(s).Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Identification of a novel HIV-1 TAR RNA bulge binding protein.Nucleic acids research · 1994Article
- Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus.The EMBO journal · 1994Article
- Effects of the Tat basic domain on human immunodeficiency virus type 1 transactivation, using chemically synthesized Tat protein and Tat peptides.Journal of virology · 1994Article
- The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.The Journal of experimental medicine · 1994Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The human immunodeficiency virus type 1 Tat protein is a powerful transactivator of the viral long terminal repeat (LTR). We have identified a cellular protein that strongly binds to Tat and can complement Tat transactivation in rodent cells. The cellular protein of about 36 kDa was isolated from extracts of human cells by Tat peptide-affinity chromatography and can form a complex with Tat in vitro. Tat transactivation is inefficient in rodent cells microinjected or transfected with the reporter plasmid pHIV-LTRCAT plus the Tat-expressing plasmid pCV-1. Remarkably, coinjection of purified 36-kDa protein with pHIV-LTRCAT plus pCV-1 stimulated Tat transactivation 2.7- to 4.9-fold. Taken together, our findings suggest that the 36-kDa protein may be a transcription factor or modulator that is important for efficient Tat transactivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.