ArticleGenes, brain, and behavior2009
Strain differences in delay discounting using inbred rats.
Article in Genes, brain, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Delay discounting of different outcomes: Review and theory.Journal of the experimental analysis of behavior · 2020Pooled it
- Cannabidiol as a Novel Candidate Alcohol Use Disorder Pharmacotherapy: A Systematic Review.Alcoholism, clinical and experimental research · 2019Pooled it
- Delayed reward discounting and addictive behavior: a meta-analysis.Psychopharmacology · 2011Pooled it
- Unveiling the Potential of Phytocannabinoids: Exploring Marijuana's Lesser-Known Constituents for Neurological Disorders.Biomolecules · 2024Review
- Genome-wide association study of delay discounting in Heterogeneous Stock rats.Genes, brain, and behavior · 2024Article
- Genome-wide association study of delay discounting in Heterogenous Stock rats.bioRxiv : the preprint server for biology · 2023Article
- Delay Discounting of Monetary and Social Media Rewards: Magnitude and Trait Effects.Frontiers in psychology · 2022Article
- Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel.Genes, brain, and behavior · 2021Article
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- Linking Delay Discounting and Substance Use Disorders: Genotypes and Phenotypes.Perspectives on behavior science · 2019Article
- Genomic basis of delayed reward discounting.Behavioural processes · 2019Review
- The relationship between delay discounting and alcohol dependence in individuals with and without comorbid psychopathology.Psychopharmacology · 2019Article
- Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.Experimental and clinical psychopharmacology · 2019Article
- Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats.Scientific reports · 2018Article
- Resurrecting the individual in behavioral analysis: Using mixed effects models to address nonsystematic discounting data.Behavior analysis (Washington, D.C.) · 2018Article
- Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds.Psychopharmacology · 2018Review
- Pair Housing Alters Delay Discounting in Lewis and Fischer 344 Rats.The Psychological record · 2018Article
- The association between parental history and delay discounting among individuals in recovery from addiction.Drug and alcohol dependence · 2017Article
- Attention-Deficit/Hyperactivity Disorder and Monetary Delay Discounting: A Meta-Analysis of Case-Control Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- The Behavioral Economics and Neuroeconomics of Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A heightened aversion to delayed rewards is associated with substance abuse and numerous other neuropsychiatric disorders. Many of these disorders are heritable, raising the possibility that delay aversion may also have a significant genetic or heritable component. To examine this possibility, we compared delay discounting in six inbred strains of rats (Brown Norway, Copenhagen, Lewis, Fischer, Noble and Wistar Furth) using the adjusting amount procedure, which provides a measure of the subjective value of delayed rewards. The subjective value of rewards decreased as the delay to receipt increased for all strains. However, a main effect of strain and a strain x delay interaction indicated that some strains were more sensitive to the imposition of delays than others. Fitting a hyperbolic discount equation showed significant strain differences in sensitivity to delay (k). These data indicate that there are significant strain differences in delay discounting. All strains strongly preferred the 10% sucrose solution (the reinforcer in the delay discounting task) over water and the amount of sucrose consumed was correlated with sensitivity to delay. Locomotor activity was not correlated with delay discounting behavior. Additional research will be required to disentangle genetic influences from maternal effects and to determine how these factors influence the underlying association between heightened delay discounting and neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.