ReviewBrain pathology (Zurich, Switzerland)2010
Global expression profiling in epileptogenesis: does it add to the confusion?
Review in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model.Neuroscience bulletin · 2026Article
- Spatiotemporal transcriptomic mapping reveals region-specific glial activation and astrocyte shifts in epileptogenesis beyond the hippocampus.Acta neuropathologica communications · 2026Article
- Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy.Acta neuropathologica · 2024Article
- Saiga antelope horn suppresses febrile seizures in rats by regulating neurotransmitters and the arachidonic acid pathway.Chinese medicine · 2024Article
- Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice.Progress in neurobiology · 2024Article
- Time and age dependent regulation of neuroinflammation in a rat model of mesial temporal lobe epilepsy: Correlation with human data.Frontiers in cell and developmental biology · 2022Article
- Relationship Between the Pyroptosis Pathway and Epilepsy: A Bioinformatic Analysis.Frontiers in neurology · 2021Article
- Bioinformatic analysis identifies key transcriptome signatures in temporal lobe epilepsy.CNS neuroscience & therapeutics · 2020Article
- Rigor and reproducibility in rodent behavioral research.Neurobiology of learning and memory · 2019Review
- Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis.BioMed research international · 2019Article
- Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets.PloS one · 2018Article
- Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene.Brain and behavior · 2017Article
- Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons.Molecular neurobiology · 2017Article
- Lipopolysaccharide potentiates hyperthermia-induced seizures.Brain and behavior · 2015Article
- The neuronal activity-driven transcriptome.Molecular neurobiology · 2015Review
- Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.Disease models & mechanisms · 2013Article
- fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- MicroRNAs in the pathophysiology and treatment of status epilepticus.Frontiers in molecular neuroscience · 2013Review
- Validation of suitable reference genes for expression studies in different pilocarpine-induced models of mesial temporal lobe epilepsy.PloS one · 2013Article
- The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis.Molecular neurobiology · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the inception of global gene expression profiling platforms in the mid-1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the first manifestation of seizures to chronic epilepsy provides the opportunity for therapeutic interventions at the molecular biology level. Using global expression profiling techniques, approximately 2000 genes have been published demonstrating differential expression in mesial temporal epilepsy. The majority of these changes, however, are specific to laboratory or experimental conditions with only 53 genes demonstrating changes in more than two publications. To this end, we review the current status of gene expression profiling in epileptogenesis and suggest standard guidelines to be followed for greater accuracy and reproducibility of results.
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