ArticleProceedings of the National Academy of Sciences of the United States of America1991
Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.Journal of neurochemistry · 2010Article
- Mechanisms of storage and exocytosis in neuroendocrine tumors.Endocrine pathology · 2004Review
- Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).Transgenic research · 2003Article
- Gene expression of receptors and enzymes involved in GABAergic and glutamatergic neurotransmission in the CNS of rats behaviourally dependent on ethanol.British journal of pharmacology · 2000Article
- Laminar difference in GABA uptake and GAT-1 expression in rat CA1.The Journal of physiology · 1998Article
- Modulation of cortical acetylcholine release by serotonin: the role of substance P interneurons.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM.Diabetologia · 1996Article
- HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus.Acta diabetologica · 1996Article
- Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.The American journal of pathology · 1995Article
- Isolation by anion-exchange of immunologically and enzymatically active human islet glutamic acid decarboxylase 65 overexpressed in Sf9 insect cells.Diabetologia · 1995Article
- Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.The Journal of clinical investigation · 1994Article
- Molecular biology of IDDM.Diabetologia · 1994Article
- Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.The Journal of experimental medicine · 1994Article
- A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM.Diabetologia · 1994Article
- Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets.Clinical and experimental immunology · 1994Article
- Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase.The Journal of clinical investigation · 1993Article
- Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.The Journal of clinical investigation · 1993Article
- Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.The Journal of clinical investigation · 1993Article
- Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.The Journal of clinical investigation · 1993Article
- Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
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6 authors.
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Abstract
A 64-kDa islet protein is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). Autoantibodies against the 64-kDa protein were recently shown to immunoprecipitate glutamic acid decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) from brain and from islets. We present evidence that the autoantisera also recognize a hydrophilic islet protein of approximately 67 kDa in addition to the amphiphilic 64-kDa form. We have isolated a full-length rat islet GAD cDNA encoding a hydrophilic 67-kDa protein, which appears to be identical to rat brain 67-kDa GAD. A partial sequence of human insulinoma 67-kDa GAD was identical to human brain 67-kDa GAD. Allelic variations were observed in rat as well as in human 67-kDa GAD sequences. The expressed rat islet 67-kDa GAD protein is functional and is immunoprecipitated by IDDM sera; it comigrates electrophoretically with the 67-kDa islet autoantigen. The hydrophilic 67-kDa form of GAD in islets is an additional autoantigen in IDDM and is recognized by a different subset of autoantibodies than the 64-kDa autoantigen. Thus, mammalian cell lines expressing functionally active, recombinant GAD may become important tools to study the nature and the role of GAD autoreactivity in IDDM.
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