ArticlePLoS biology2009
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes inFrontiers in oncology · 2026Article
- Epithelial cell competition is promoted by signaling from immune cells.Nature communications · 2025Article
- Using Drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer.Trends in cancer · 2024Review
- Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks.Molecular cell · 2021Article
- Review
- MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Role of Neurodevelopmental Pathways in Brain Tumors.Frontiers in cell and developmental biology · 2021Review
- Rounding up the Usual Suspects: Assessing Yorkie, AP-1, and Stat Coactivation in Tumorigenesis.International journal of molecular sciences · 2020Article
- Bidirectional Regulation of Sleep and Synapse Pruning after Neural Injury.Current biology : CB · 2020Article
- Salt inducible kinases as novel Notch interactors in the developing Drosophila retina.PloS one · 2020Article
- An in vivo RNAi mini-screen in Drosophila cancer models reveals novel potential Wnt targets in liver cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models.Journal of hematology & oncology · 2018Article
- A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor ineLife · 2018Article
- Modelling Cooperative Tumorigenesis inBioMed research international · 2018Review
- LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans.Scientific reports · 2017Article
- Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.The Journal of biological chemistry · 2016Article
- Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons.Development (Cambridge, England) · 2016Article
- Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.Developmental biology · 2016Article
- Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition.Nature communications · 2015Article
- ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of differentiation may be key regulators of tumor formation. Using loss- and gain-of-function analyses in Drosophila, we describe a critical anti-oncogenic function for the atonal transcription factor in the fly retina, where atonal instructs tissue differentiation. In the tumor context, atonal acts by regulating cell proliferation and death via the JNK stress response pathway. Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.