ArticleJournal of magnetic resonance imaging : JMRI2009
Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Between Prometheus and Thanatos: Reflections on Intracardiac Injection Models for Metastasis in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Review
- Imaging pheochromocytoma in small animals: preclinical models to improve diagnosis and treatment.EJNMMI research · 2021Review
- Strain-specific metastatic phenotypes in pheochromocytoma allograft miceEndocrine-related cancer · 2018Article
- Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis.Cell and tissue research · 2018Review
- Highly metastatic K7M2 cell line: A novel murine model capable of in vivo imaging via luciferase vector transfection.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma.Endocrinology · 2014Article
- The utility of micro-CT and MRI in the assessment of longitudinal growth of liver metastases in a preclinical model of colon carcinoma.Academic radiology · 2013Article
- Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?Endocrine pathology · 2012Review
- Lung tumour growth kinetics in SPC-c-Raf-1-BB transgenic mice assessed by longitudinal in-vivo micro-CT quantification.Journal of experimental & clinical cancer research : CR · 2012Article
- Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma.Nuclear medicine and biology · 2012Article
- Quantitative analysis of tumor burden in mouse lung via MRI.Magnetic resonance in medicine · 2012Article
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- Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model.Lasers in surgery and medicine · 2011Article
- Article
- Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹⁸F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors.Endocrine-related cancer · 2011Article
- Micro-CT based experimental liver imaging using a nanoparticulate contrast agent: a longitudinal study in mice.PloS one · 2011Article
- Successful establishment of an orthotopic hepatoblastoma in vivo model in NOD/LtSz-scid IL2Rγnull mice.PloS one · 2011Article
- In vivo micro-CT imaging of liver lesions in small animal models.Methods (San Diego, Calif.) · 2010Review
- Animal model of metastatic pheochromocytoma: evaluation by MRI and PET.Endocrine regulations · 2009Article
- Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature.Clinical & experimental metastasis · 2009Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 2 countries.
Funding
Abstract
purposeTo compare contrast-enhanced micro-computed tomography (microCT) and nonenhanced respiratory-triggered magnetic resonance imaging (MRI) in an animal model of metastatic pheochromocytoma. Animal models are becoming important in the study of cancer treatment and imaging is useful in minimizing the number of animals needed and reducing costs associated with autopsies. However, the choice of imaging modality is still evolving. MATERIALS AND
methodsAdult female nude mice were injected by tail vein with a mouse pheochromocytoma (MPC) cell line (MPC 4/30PRR) to create a metastatic model. After optimizing imaging techniques, eight mice were imaged with both respiratory triggered MRI and microCT and the findings were verified histologically.
resultsMicroCT and MRI were approximately equal in their ability to detect hepatic metastases at a size threshold of 350 microm. In the lungs, MRI was more sensitive than microCT, detecting lesions 0.6 mm in diameter versus 1 mm for microCT. Additionally, MRI was more sensitive for lesions in the kidneys, bone, ovaries, and adrenal glands. MRI demonstrated a higher contrast-to-noise ratio (CNR) than microCT.
conclusionIn addition to the advantage of not exposing the animal to ionizing radiation, MRI provided a more complete assessment of the extent of metastases in this model compared to microCT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.