Evidence map›Paper›PMID 19242795›Full record

ArticleDigestive diseases and sciences2010

Coronary artery disease in patients with liver cirrhosis.

Evangelos Kalaitzakis, Annika Rosengren, Tomas Skommevik, Einar Björnsson

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Experimental Liver Cirrhosis Inhibits Restenosis after Balloon Angioplasty.International journal of molecular sciences · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Management of Acute Coronary Syndrome in Patients with Liver Cirrhosis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. SPECT myocardial perfusion imaging in liver transplantation candidates.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  14. Review
  15. The relationship between coronary artery disease and cardiovascular events early after liver transplantation.Liver international : official journal of the International Association for the Study of the Liver · 2019
    Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Elevated Fasting Plasma Glucose before Liver Transplantation is Associated with Lower Post-Transplant Survival.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Evangelos KalaitzakisDepartment of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden. evangelos.kalaitzakis@vgregion.se
Annika Rosengren
Tomas Skommevik
Einar Björnsson
Sahlgrenska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of coronary artery disease (CAD) has been reported to be low in patients with liver cirrhosis. Previous studies have, however, included mostly patients with cirrhosis due to hepatitis C. We aimed to determine the prevalence and predictive factors of CAD in a cohort of consecutive patients with cirrhosis of various etiologies compared to the general population.

methodsA total of 127 patients with cirrhosis were evaluated for a history of CAD and cardiovascular risk factors. Arterial blood pressure, fasting plasma glucose, and serum cholesterol were measured. Nutritional status was assessed by anthropometry and estimation of recent weight change. A group of 203 subjects from the general population with similar age and gender distribution, as well as smoking habits as the cirrhotic patients, served as controls.

resultsCAD was more common in cirrhotics compared to controls (20% vs. 12%, P = 0.001). Compared to controls, cirrhotics had lower mean arterial blood pressure and serum cholesterol and a higher prevalence of diabetes, but did not differ significantly in the prevalence of hypertension or family history for CAD. In regression analysis, CAD was independently related to diabetes (odds ratio [OR] 5.47, 95% confidence interval [CI] 2.44-12.28), but not to liver cirrhosis. In the cirrhosis group, only alcoholic cirrhosis (OR 9.50, 95% CI 1.08-83.4) and age (OR 1.23 per year, 95% CI 1.06-1.43) were independently related to CAD.

conclusionsLiver cirrhosis, per se, does not seem to confer a protective effect against CAD. In cirrhotics, older age and alcoholic etiology were independently related to CAD.

Indexed as

Age DistributionCoronary Artery DiseaseElectrocardiographyFemaleFollow-Up StudiesHumansLiver CirrhosisMaleMiddle AgedOdds RatioPrevalenceRetrospective StudiesRisk FactorsSex DistributionSweden

Identifiers

PMID19242795
OpenAlexW2064464327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.