ArticlePLoS computational biology2009
Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction.Life science alliance · 2025Article
- HillTau: A fast, compact abstraction for model reduction in biochemical signaling networks.PLoS computational biology · 2021Article
- From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity.Seminars in cell & developmental biology · 2019Review
- Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4.Science signaling · 2019Article
- PIPScientific reports · 2019Article
- Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.Scientific reports · 2018Article
- FindSim: A Framework for Integrating Neuronal Data and Signaling Models.Frontiers in neuroinformatics · 2018Article
- Understanding the mTOR signaling pathway via mathematical modeling.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- A systems study reveals concurrent activation of AMPK and mTOR by amino acids.Nature communications · 2016Article
- Systems Biology of Immunomodulation for Post-Stroke Neuroplasticity: Multimodal Implications of Pharmacotherapy and Neurorehabilitation.Frontiers in neurology · 2016Article
- Enabling surface dependent diffusion in spatial simulations using Smoldyn.BMC research notes · 2015Article
- Transcription control pathways decode patterned synaptic inputs into diverse mRNA expression profiles.PloS one · 2014Article
- Approaches and tools for modeling signaling pathways and calcium dynamics in neurons.Journal of neuroscience methods · 2013Review
- Computational modelling of the regulation of Insulin signalling by oxidative stress.BMC systems biology · 2013Article
- The protein kinase Mζ network as a bistable switch to store neuronal memory.BMC systems biology · 2010Article
- Postsynaptic signal transduction models for long-term potentiation and depression.Frontiers in computational neuroscience · 2010Article
- Article
- Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in synaptic efficacy are believed to form the cellular basis for memory. Protein synthesis in dendrites is needed to consolidate long-term synaptic changes. Many signals converge to regulate dendritic protein synthesis, including synaptic and cellular activity, and growth factors. The coordination of these multiple inputs is especially intriguing because the synthetic and control pathways themselves are among the synthesized proteins. We have modeled this system to study its molecular logic and to understand how runaway feedback is avoided. We show that growth factors such as brain-derived neurotrophic factor (BDNF) gate activity-triggered protein synthesis via mammalian target of rapamycin (mTOR). We also show that bistability is unlikely to arise from the major protein synthesis pathways in our model, even though these include several positive feedback loops. We propose that these gating and stability properties may serve to suppress runaway activation of the pathway, while preserving the key role of responsiveness to multiple sources of input.
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