Trial reportJournal of the International Neuropsychological Society : JINS2009
Errorless practice as a possible adjuvant to donepezil in Alzheimer's disease.
Trial report in Journal of the International Neuropsychological Society : JINS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- A prospective test of the late effects of potentially antineuroplastic drugs in a stroke rehabilitation study.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity.Frontiers in molecular neuroscience · 2020Article
- A Comparison of Memory Beliefs, Cognitive Activity, and Depression Among Healthy Older Adults, Amnestic Mild Cognitive Impairment, and Patient with Alzheimer's Disease.Annals of geriatric medicine and research · 2019Article
- How to constrain and maintain a lexicon for the treatment of progressive semantic naming deficits: Principles of item selection for formal semantic therapy.Neuropsychological rehabilitation · 2016Article
- The relevance of aging-related changes in brain function to rehabilitation in aging-related disease.Frontiers in human neuroscience · 2015Article
- Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI.Neurobiology of learning and memory · 2013Article
- Lexicality Effects in Word and Nonword Recall of Semantic Dementia and Progressive Nonfluent Aphasia.Aphasiology · 2012Article
- Visual discrimination predicts naming and semantic association accuracy in Alzheimer disease.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2010Article
- Language and communication non-pharmacological interventions in patients with Alzheimer's disease: a systematic review. Communication intervention in Alzheimer.Dementia & neuropsychologiaArticle
- Treatment of Alzheimer's disease in Brazil: I. Cognitive disorders.Dementia & neuropsychologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Six individuals with probable Alzheimer's disease (AD) participated in a phase 1 study employing a repeated measures, parallel baseline design testing the hypothesis that error-free experience during word production practice combined with an acetyl cholinesterase inhibitor would improve confrontation naming ability. While acetyl cholinesterase inhibitors are safe and delay cognition decline associated with AD, improvement over baseline cognition is less evident; clinically significant cognitive deficits persist and progress. Both animal and clinical research strongly implicate acetylcholine in learning, a form of neuroplasticity. In clinical practice, however, people with AD are given cholinergic medications without concomitant systematic/targeted retraining. In this study six participants with probable AD and taking donepezil participated in targeted word production practice using an errorless learning strategy. Results showed that combining behavioral enrichment training and an acetyl cholinesterase inhibitor resulted in significant improvements in verbal confrontation naming of trained items for three of six participants. Differences in baseline dementia severity, living conditions, and medications may have influenced the training response. Detection of substantial treatment effects in 50% of subjects suggests further language treatment studies in AD in combination with an acetyl cholinesterase inhibitor are warranted and provide useful information on inclusion/exclusion criteria for use in subsequent studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.