Trial reportInternational journal of colorectal disease2009
ETVARD (endoscopic transanal vacuum-assisted rectal drainage) leads to complete but delayed closure of extraperitoneal rectal anastomotic leakage cavities following neoadjuvant radiochemotherapy.
Trial report in International journal of colorectal disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Endoscopic Treatment Options for Gastrointestinal Leaks.Visceral medicine · 2022Pooled it
- Endoscopic vacuum therapy and early surgical closure after pelvic anastomotic leak: meta-analysis of bowel continuity rates.The British journal of surgery · 2022Pooled it
- Endoscopic vacuum therapy for the treatment of colorectal leaks - a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- The use of Endo-SPONGETechniques in coloproctology · 2020Pooled it
- Early anastomotic complications in colorectal surgery: a systematic review of techniques for endoscopic salvage.Surgical endoscopy · 2019Pooled it
- Systematic review of endoluminal vacuum-assisted therapy as salvage treatment for rectal anastomotic leakage.BJS open · 2019Pooled it
- Article
- Unveiling a rare adverse event: sponge migration during endoscopic vacuum therapy for colorectal anastomotic leak.iGIE : innovation, investigation and insights · 2024Article
- Influence of Neoadjuvant Therapy on Success of Endoscopic Vacuum Therapy in Anastomotic Leakage after Rectal Resection Because of Rectal Cancer.Journal of clinical medicine · 2024Article
- Rectal perforation and perirectal abscess following stapled hemorrhoidectomy for prolapsed hemorrhoids successfully managed with Endo-SPONGE endoluminal vacuum-assisted wound closure system.Annals of coloproctology · 2022Article
- Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage: A critical analysis.World journal of gastroenterology · 2022Review
- Management of colorectal anastomotic leakage using endoscopic negative pressure therapy with or without protective ostomy: a retrospective study.International journal of colorectal disease · 2021Article
- Endo-sponge in management of anastomotic colorectal leaks: a systematic review and meta-analysis.Endoscopy international open · 2021Article
- Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects.World journal of gastrointestinal endoscopy · 2019Review
- First UK experience of endoscopic vacuum therapy for the management of oesophageal perforations and postoperative leaks.Frontline gastroenterology · 2019Article
- Long-term efficacy of vacuum-assisted therapy (Endo-SPONGEAnnals of gastroenterology · 2017Article
- Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Review
- Treatment of Iatrogenic esophageal perforation: Do we need another tool?Endoscopy international open · 2015Article
- Endoscopic vacuum therapy for esophageal perforations and leakages.Endoscopy international open · 2015Article
- Endoscopic vacuum-assisted closure system (E-VAC): case report and review of the literature.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of the study was to prospectively assess the impact of neoadjuvant radiochemotherapy on the formation of major anastomotic rectal leaks and treatment by endoscopic transanal vacuum-assisted rectal drainage (ETVARD). MATERIALS AND
methodsTwenty six patients with malignancies with rectal anastomotic leaks were prospectively treated, including 14 of 26 patients following neoadjuvant radiochemotherapy. ETVARD was the first-line treatment.
resultsIn 23 of 26 patients, ETVARD was successfully completed. In patients following neoadjuvant radiochemotherapy sizes of leakage cavities, duration of ETVARD, number of sponge exchanges, and endoscopies as well as time to closure of cavities were significantly increased (0.009 < p < 0.035) compared to patients after primary surgery. Increased age showed similar correlations, whereas the level of anastomoses did not influence these parameters. Patients without (ile)ostomies could also be treated by ETVARD. Follow-up endoscopies have not shown any major changes.
conclusionsRadiochemotherapy has a significant impact on development and treatment of major anastomotic rectal leaks. Most patients can be successfully treated by ETVARD, avoiding additional resective surgery or permanent (col)ostomies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.