ArticleInternational journal of biological sciences2009
Is sodium current present in human sinoatrial node cells?
Article in International journal of biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology.American journal of physiology. Heart and circulatory physiology · 2024Article
- Genetics of sinoatrial node function and heart rate disorders.Disease models & mechanisms · 2023Review
- Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier KInternational journal of molecular sciences · 2023Article
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- Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node.Nature communications · 2020Article
- Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2019Review
- A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.Science signaling · 2018Article
- Kir2 inward rectification-controlled precise and dynamic balances between Kir2 and HCN currents initiate pacemaking activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Sinus Bradycardia in Carriers of the SCN5A-1795insD Mutation: Unraveling the Mechanism through Computer Simulations.International journal of molecular sciences · 2018Article
- Cellular Mechanisms of Sinus Node Dysfunction in Carriers of theFrontiers in physiology · 2018Article
- Computational analysis of the human sinus node action potential: model development and effects of mutations.The Journal of physiology · 2017Article
- β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.Journal of physiology and biochemistry · 2016Article
- The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Review
- HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates.Journal of the American College of Cardiology · 2013Article
- Calcium transient and sodium-calcium exchange current in human versus rabbit sinoatrial node pacemaker cells.TheScientificWorldJournal · 2013Article
- Difference of sodium currents between pediatric and adult human atrial myocytes: evidence for developmental changes of sodium channels.International journal of biological sciences · 2011Article
- Cardiac sodium channelopathies.Pflugers Archiv : European journal of physiology · 2010Review
- Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome.PloS one · 2010Article
- Effects of tetrodotoxin on the mammalian cardiovascular system.Marine drugs · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatrial node. In 2 out of the 3 cells measured, we observed large inward currents with characteristics of I(Na). Although we were unable to analyze the current in detail, our findings provide strong evidence that I(Na) is present in human sinoatrial node pacemaker cells, and that this I(Na) is functionally available at potentials negative to -60 mV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.