Evidence map›Paper›PMID 19239748›Full record

ArticleEmerging infectious diseases2009

Shiga toxin-producing Escherichia coli strains negative for locus of enterocyte effacement.

Hayley J Newton, Joan Sloan, Dieter M Bulach, Torsten Seemann, Cody C Allison, Marija Tauschek, Roy M Robins-Browne, James C Paton, Thomas S Whittam, Adrienne W Paton and 1 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Article
  2. Review
  3. Escherichia coli O157:H7 strains in bovine carcasses and the impact on the animal production chain.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Review
  4. Detection and analysis of Shiga toxin producing and enteropathogenic Escherichia coli in cattle from Tierra del Fuego, Argentina.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  5. Article
  6. Molecular serotyping of Shiga toxin-producingVeterinary research forum : an international quarterly journal · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Shiga Toxin-ProducingMicroorganisms · 2022
    Review
  12. Review
  13. IgG BindsFrontiers in immunology · 2022
    Article
  14. Characterization ofFoods (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hayley J NewtonMonash University, Melbourne, Victoria, Australia.
Joan Sloan
Dieter M Bulach
Torsten Seemann
Cody C Allison
Marija Tauschek
Roy M Robins-Browne
James C Paton
Thomas S Whittam
Adrienne W Paton
Elizabeth L Hartland

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most Shiga toxin-producing Escherichia coli (STEC) infections that are associated with severe sequelae such as hemolytic uremic syndrome (HUS) are caused by attaching and effacing pathogens that carry the locus of enterocyte effacement (LEE). However, a proportion of STEC isolates that do not carry LEE have been associated with HUS. To clarify the emergence of LEE-negative STEC, we compared the genetic composition of the virulence plasmids pO113 and pO157 from LEE-negative and LEE-positive STEC, respectively. The complete nucleotide sequence of pO113 showed that several plasmid genes were shared by STEC O157:H7. In addition, allelic profiling of the ehxA gene demonstrated that pO113 belongs to a different evolutionary lineage than pO157 and that the virulence plasmids of LEE-negative STEC strains were highly related. In contrast, multilocus sequence typing of 17 LEE-negative STEC isolates showed several clonal groups, suggesting that pathogenic LEE-negative STEC has emerged several times throughout its evolution.

Indexed as

Bacterial Typing TechniquesDNA HelicasesEscherichia coli O157Escherichia coli ProteinsHemolysin ProteinsHemolytic-Uremic SyndromeHumansPhosphoproteinsPhylogenyPlasmidsSequence Analysis, DNAShiga-Toxigenic Escherichia coliTrans-ActivatorsVirulenceDNA HelicasesEscherichia coli ProteinsHemolysin ProteinsHlya protein, E coliLEE protein, E coliPhosphoproteinsreplication initiator proteinTrans-Activators

Identifiers

PMID19239748
PMCPMC2681110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.