ArticleMolecular microbiology2009
Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Structure and Mechanism of DHHC Protein Acyltransferases.Journal of molecular biology · 2020Review
- Article
- Article
- Cysteine proteases in protozoan parasites.PLoS neglected tropical diseases · 2018Review
- A Calpain-Like Protein Is Involved in the Execution Phase of Programmed Cell Death ofFrontiers in cellular and infection microbiology · 2018Article
- Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor.Cell host & microbe · 2017Article
- Dynamic protein S-palmitoylation mediates parasite life cycle progression and diverse mechanisms of virulence.Critical reviews in biochemistry and molecular biology · 2017Review
- Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcγR-mediated phagocytosis.Journal of leukocyte biology · 2017Article
- Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.PloS one · 2015Article
- Article
- Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes.Eukaryotic cell · 2014Article
- Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.Nature chemistry · 2014Article
- Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.The Journal of biological chemistry · 2013Article
- Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.Traffic (Copenhagen, Denmark) · 2013Article
- N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization.Biochimica et biophysica acta · 2013Article
- Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development.Malaria journal · 2013Article
- Plasmodium berghei MAPK1 displays differential and dynamic subcellular localizations during liver stage development.PloS one · 2013Article
- Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum.The Journal of biological chemistry · 2012Article
- Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.Cell host & microbe · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Plasmodium falciparum genome encodes a single calpain. By generating P. falciparum clones expressing C-terminally tagged calpain, we localized this protein to the nucleolus. Pf_calpain possesses an unusual and long N-terminal domain in which we identified three subregions that are highly conserved among Plasmodium species. Two have putative targeting signals: a myristoylation motif and a nuclear localization sequence. We assessed their functionality. Our data show that the nuclear localization sequence is an active nuclear import motif that contains an embedded signal conferring nucleolar localization on various chimeras. The N-terminus is myristoylated at Gly2 and palmitoylated at Cys3 and Cys22. Palmitoylation status has an important role in dictating P. falciparum calpain localization. The targeting signals function in mammalian cells as well as in the parasite. P. falciparum calpain is a unique nucleolar protein with an interesting mechanism of targeting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.