ReviewFEMS immunology and medical microbiology2009
Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance?
Review in FEMS immunology and medical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis.Colombia medica (Cali, Colombia) · 2015Pooled it
- Article
- Review
- Immune-Mediated Pathogenesis in Dengue Virus Infection.Viruses · 2022Review
- Pathogen-induced inflammation is attenuated by the iminosugar MON-DNJ via modulation of the unfolded protein response.Immunology · 2021Article
- Host-virus interaction and viral evasion.Cell biology international · 2021Review
- Nitric Oxide to Fight Viral Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Dengue and metabolomics in humans.Metabolomics : Official journal of the Metabolomic Society · 2021Review
- Expression of Nitric Oxide Synthase and Nitric Oxide Levels in Peripheral Blood Cells and Oxidized Low-Density Lipoprotein Levels in Saliva as Early Markers of Severe Dengue.BioMed research international · 2021Article
- Dengue Virus Infection ofInternational journal of molecular sciences · 2020Article
- Article
- Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses.Viruses · 2019Review
- Role of TNF α, IL-6 and CXCL10 in Dengue disease severity.Iranian journal of microbiology · 2018Article
- Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?Disease markers · 2018Article
- Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection.PLoS neglected tropical diseases · 2018Article
- Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study.Scientific reports · 2017Article
- Biomarkers of severe dengue disease - a review.Journal of biomedical science · 2015Review
- Differential regulation of angiopoietin 1 and angiopoietin 2 during dengue virus infection of human umbilical vein endothelial cells: implications for endothelial hyperpermeability.Medical microbiology and immunology · 2013Article
- Nitric oxide synthase expression correlates with death in an experimental mouse model of dengue with CNS involvement.Virology journal · 2013Article
- Dengue in India.The Indian journal of medical research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in free radical research show that reactive oxygen and nitrogen oxide species, for example superoxide, nitric oxide (NO) and peroxynitrite, play an important role in the pathogenesis of different viral infections, including dengue virus. The pathogenic mechanism of dengue haemorrhagic fever (DHF) is complicated and is not clearly understood. The hallmarks of the dengue disease, the antibody-dependent enhancement, the shift from T-helper type 1 (Th1) to Th2 cytokine response and the cytokine tsunami resulting in vascular leakage can now be explained much better with the knowledge gained about NO and peroxynitrite. This paper makes an effort to present a synthesis of the current opinions to explain the pathogenesis of DHF/shock syndrome with NO on centre stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.