ArticleAging cell2009
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.
Article in Aging cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Sex-dependent adaptations in heart mitochondria from transgenic mice overexpressing cytochrome bMitochondrion · 2025Article
- Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster.Insect science · 2024Article
- Identification of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration.Frontiers in immunology · 2024Article
- The diverse functionality of NQO1 and its roles in redox control.Redox biology · 2021Review
- NQO1 Binds and Supports SIRT1 Function.Frontiers in pharmacology · 2021Article
- Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.Ageing research reviews · 2020Review
- Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging.Biomolecules · 2020Review
- Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure.Molecular metabolism · 2020Article
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.Ageing research reviews · 2017Review
- Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration.NPJ aging and mechanisms of disease · 2017Article
- Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.Nature communications · 2016Article
- Calorie restriction as an intervention in ageing.The Journal of physiology · 2016Review
- CytochromeNPJ aging and mechanisms of disease · 2016Article
- Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics.Age (Dordrecht, Netherlands) · 2015Article
- Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.Antioxidants & redox signaling · 2014Article
- The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.The Journal of biological chemistry · 2013Article
- Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+ depletion in fermenting yeast.The Journal of biological chemistry · 2013Article
- Sirtuin activation: a role for plasma membrane in the cell growth puzzle.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.PloS one · 2012Article
- NRF2, cancer and calorie restriction.Oncogene · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.