ArticleSleep2009
Obstructive sleep apnea leads to transient uncoupling of coronary blood flow and myocardial work in humans.
Article in Sleep, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03517150 (Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Acoustic Analysis of Snoring in the Diagnosis of Obstructive Sleep Apnea Syndrome: A Call for More Rigorous Studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Guideline
- The association between sleep fragmentation and incident atrial fibrillation: a prospective cohort study in a community population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes.Current cardiology reports · 2024Review
- Comorbidity Profile and Predictors of Obstructive Sleep Apnea Severity and Mortality in Non-Obese Obstructive Sleep Apnea Patients.Medicina (Kaunas, Lithuania) · 2023Article
- The impact of sleep disordered breathing on cardiac troponin in acutely decompensated heart failure.Sleep & breathing = Schlaf & Atmung · 2023Article
- Recognition of Patient Groups with Sleep Related Disorders using Bio-signal Processing and Deep Learning.Sensors (Basel, Switzerland) · 2020Article
- Severe obstructive sleep apnea is associated with significant coronary artery plaque burden independent of traditional cardiovascular risk factors.The international journal of cardiovascular imaging · 2020Article
- Sleep Disordered Breathing and Cardiovascular Diseases.Journal of atherosclerosis and thrombosis · 2019Review
- A Novel Sleep Respiratory Rate Detection Method for Obstructive Sleep Apnea Based on Characteristic Moment Waveform.Journal of healthcare engineering · 2018Article
- Obstructive sleep apnea and acute coronary syndromes: etiology, risk, and management.Current cardiology reports · 2014Review
- Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury.Sleep & breathing = Schlaf & Atmung · 2013Article
- Review
- Sleep apnea monitoring and diagnosis based on pulse oximetry and tracheal sound signals.Medical & biological engineering & computing · 2010Article
- Coronary flow reserve is impaired in patients with obstructive sleep apnea.Annals of thoracic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesObstructive Sleep Apnea (OSA) is associated with a poor prognosis in patients with coronary artery disease. We hypothesized that abnormalities of coronary blood flow (CBF) associated with obstructive apneas may predispose patients to ischemia. We aimed to determine CBF during respiratory events in patients with OSA.
settingUniversity Hospital. PATIENTS: Ten subjects undergoing elective percutaneous coronary intervention
designWe measured CBF and myocardial work (rate-pressure product [RPP]) in a non-culprit coronary artery in patients sleeping in the cardiac catheterization laboratory. Hemodynamic responses were matched to spontaneously occurring respiratory events. MEASUREMENTS AND
resultsEvents comprised a mixture of obstructive apneas, central apneas and hypopneas. RPP increased at the termination of each type of respiratory event. Following the rise in RPP, there was a delay, identified with breakpoint analysis, before CBF began to increase (P<0.001) that differed in duration with event type: 8 sec for obstructive apnea, 5 sec for central apnea, and 4 sec for hypopnea. The delay in CBF with obstructive apnea was associated with an increase in coronary vascular resistance of 16% +/- 4% (P < 0.05). Stepwise multilinear regression analysis showed the increase in CBF was predicted by the rise in RPP (R=0.52, P<0.001) and presence of arousal from sleep (R=0.30, P<0.05), but not the degree of O2 desaturation.
conclusionFollowing obstructive apneas there is a transient uncoupling of CBF from myocardial work and an increase in CVR. This disturbed flow-metabolic coupling may lead to nocturnal myocardial ischemia in patients with both OSA and coronary artery disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.