Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

1. Sleep quality, disturbance and the prevalence of obstructive sleep apnoea in chronic spontaneous urticaria and associated risk factors.The World Allergy Organization journal · 2026
   Article
2. Health, social and economic consequences of hypersomnia: a controlled national study from a national registry evaluating the societal effect on patients and their partners.The European journal of health economics : HEPAC : health economics in prevention and care · 2014
   Article
3. Can transcranial magnetic stimulation be used to evaluate patients with narcolepsy?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013
   Article
4. The histaminergic network in the brain: basic organization and role in disease.Nature reviews. Neuroscience · 2013
   Review
5. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions.Sleep · 2012
   Article
6. Inability to replicate cerebrospinal fluid histamine deficits in the primary hypersomnias: a back to the drawing board moment.Sleep · 2012
   Article
7. Histamine in the regulation of wakefulness.Sleep medicine reviews · 2011
   Review

Corrections and comments

• Comment on
  CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome.2009

Authors and funding

2 authors at 1 institution in 1 country.

Funding

Abstract

PubMed holds no abstract for this paper.

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