ArticleMolecular and cellular biochemistry2009
Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Physical activity offsets the negative effects of a high-fructose diet.Medicine and science in sports and exercise · 2014Trial
- Effect of High Fructose Corn Syrup and Citric Acid in Broiler Diets on Performance, Gut pH, Immunity, Antioxidant Status and Some Blood Parameters.Veterinary medicine and science · 2025Article
- Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats.Scientific reports · 2017Article
- Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.Journal of lipids · 2015Review
- Effect of fructooligosaccharides fraction from Psacalium decompositum on inflammation and dyslipidemia in rats with fructose-induced obesity.Nutrients · 2014Article
- Article
- Substitution of soy protein for casein prevents oxidative modification and inflammatory response induced in rats fed high fructose diet.ISRN inflammation · 2014Article
- Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization.Endocrinology · 2012Article
- Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats.Journal of Zhejiang University. Science. B · 2012Article
- Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats.Nutrition & metabolism · 2011Article
- A Regenerative Antioxidant Protocol of Vitamin E and α-Lipoic Acid Ameliorates Cardiovascular and Metabolic Changes in Fructose-Fed Rats.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels.Pharmacology, biochemistry, and behavior · 2010Article
- Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats.International journal of medical sciences · 2010Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.