Evidence map›Paper›PMID 19238523›Full record

ArticleMolecular and cellular biochemistry2009

Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats.

Mohammad M Abdullah, Natalie N Riediger, Qilin Chen, Zhaohui Zhao, Nazila Azordegan, Zuyuan Xu, Gabor Fischer, Rgia A Othman, Grant N Pierce, Paramjit S Tappia and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Physical activity offsets the negative effects of a high-fructose diet.Medicine and science in sports and exercise · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mohammad M AbdullahDepartments of Human Nutritional Sciences, The University of Manitoba and St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada.
Natalie N Riediger
Qilin Chen
Zhaohui Zhao
Nazila Azordegan
Zuyuan Xu
Gabor Fischer
Rgia A Othman
Grant N Pierce
Paramjit S Tappia
Jitao Zou
Mohammed H Moghadasian
St. Boniface Hospital · CAUniversity of Manitoba · CAPlant Biotechnology Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.

Indexed as

AnimalsBlood GlucoseBlood PressureBody WeightCardiovascular DiseasesCytokinesDietary CarbohydratesEatingFructoseGlucose Tolerance TestInsulinIntra-Abdominal FatLipidsMaleRatsRats, Sprague-DawleyBlood GlucoseCytokinesDietary CarbohydratesFructoseInsulinLipids

Identifiers

PMID19238523
OpenAlexW1971930077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.