ArticleVirchows Archiv : an international journal of pathology2009
Diagnosis of autoimmune pancreatitis by core needle biopsy: application of six microscopic criteria.
Article in Virchows Archiv : an international journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.United European gastroenterology journal · 2020Guideline
- Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Usefulness of core needle biopsy of thyroid for the diagnosis of IgG4 Hashimoto's thyroiditis.Journal of translational internal medicine · 2026Article
- The Role of Endoscopic Ultrasound and Ancillary Techniques in the Diagnosis of Autoimmune Pancreatitis: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Challenges for clinicians treating autoimmune pancreatitis: Current perspectives.World journal of clinical cases · 2023Review
- Concordance of the histological diagnosis of type 1 autoimmune pancreatitis and its distinction from pancreatic ductal adenocarcinoma with endoscopic ultrasound-guided fine needle biopsy specimens: an interobserver agreement study.Virchows Archiv : an international journal of pathology · 2022Article
- Article
- The Role of EUS-Guided FNA and FNB in Autoimmune Pancreatitis.Diagnostics (Basel, Switzerland) · 2021Review
- Role of Endoscopic Procedures in the Diagnosis of IgG4-Related Pancreatobiliary Disease.Chonnam medical journal · 2021Review
- [IgG4-related disease : Microscopic diagnosis and differential diagnosis].Der Pathologe · 2019Review
- Article
- IgG4-related disease: with emphasis on the biopsy diagnosis of autoimmune pancreatitis and sclerosing cholangitis.Virchows Archiv : an international journal of pathology · 2018Review
- Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management.The American journal of gastroenterology · 2017Review
- Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience.Gastroenterology research and practice · 2017Article
- [Histopathology of IgG4-related disease].Zeitschrift fur Rheumatologie · 2016Review
- Comparison study of immunohistochemical staining for the diagnosis of type 1 autoimmune pancreatitis.Journal of gastroenterology · 2015Article
- The importance of IgG4 in the predictive model of thyroiditis.Endocrinology, diabetes & metabolism case reports · 2015Article
- Diagnosis of autoimmune pancreatitis.World journal of gastroenterology · 2014Review
- [Autoimmune pancreatitis--treatment and pitfalls in diagnostics].Der Internist · 2014Article
- [Immunoglobulin G4 (IgG4)-related disease. A review of head and neck manifestations].Der Pathologe · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune pancreatitis (AIP) has been established as a special entity of chronic pancreatitis (CP). However, its clinical distinction from pancreatic cancer and other types of CP is still difficult. The aim of this study was to evaluate the efficacy of pancreatic core needle biopsy for the diagnosis of AIP. In 44 core needle biopsy specimens, we assessed the following microscopic features: granulocytic epithelial lesions (GELs), more than ten IgG4-positive plasma cells/HPF, more than ten eosinophilic granulocytes/HPF, cellular fibrosis with inflammation, lymphoplasmacytic infiltration, and venulitis. All biopsies that showed four or more of the six features (22 of 44) were obtained from 21 of 26 patients whose clinical diagnosis and follow-up were consistent with AIP. All non-AIP CP patients (n = 14) showed three or less than three of the features in their biopsies. GELs were only observed in biopsy specimens from AIP patients. In conclusion, our data indicate that the six criteria we applied were able to recognize AIP in 76% of biopsy specimens using a cut-off level of four. When the specimens that revealed only three features but showed GELs were added, the sensitivity rose to 86%. Pancreatic core needle biopsy can therefore make a significant contribution to the diagnosis of AIP.
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