ArticleJournal of molecular medicine (Berlin, Germany)2009
Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis.
Article in Journal of molecular medicine (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- WISP1 and Macrophage Migration Inhibitory Factor in Respiratory Inflammation: Novel Insights and Therapeutic Potentials for Asthma and COPD.International journal of molecular sciences · 2024Review
- Rauwolfia polysaccharide can inhibit the progress of ulcerative colitis through NOS2-mediated JAK2/STAT3 pathway.PloS one · 2024Article
- Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years.Skeletal muscle · 2022Article
- The Effects of WISP1 Polymorphisms on the Prognosis of Lung Cancer Patients with Platinum-Based Chemotherapy.Pharmacogenomics and personalized medicine · 2021Article
- Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.Aging cell · 2019Article
- miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPARγ and Occludin Expression in Chronic Simian Immunodeficiency Virus-Infected Rhesus Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling.JCI insight · 2018Article
- The role of CCN4/WISP-1 in the cancerous phenotype.Cancer management and research · 2018Review
- Shigella dysenteriae infection activates proinflammatory response through β-catenin/NF-κB signaling pathway.PloS one · 2017Article
- WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease.Disease markers · 2016Article
- The dual role of iNOS in cancer.Redox biology · 2015Review
- A functional analysis of Wnt inducible signalling pathway protein -1 (WISP-1/CCN4).Journal of cell communication and signaling · 2015Article
- Arginine enhances osteoblastogenesis and inhibits adipogenesis through the regulation of Wnt and NFATc signaling in human mesenchymal stem cells.International journal of molecular sciences · 2014Article
- Novel therapeutic targets in depression and anxiety: antioxidants as a candidate treatment.Current neuropharmacology · 2014Article
- WISP1: Clinical insights for a proliferative and restorative member of the CCN family.Current neurovascular research · 2014Review
- CCN4 regulates vascular smooth muscle cell migration and proliferation.Molecules and cells · 2013Article
- Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Wnt2 inhibits enteric bacterial-induced inflammation in intestinal epithelial cells.Inflammatory bowel diseases · 2012Article
- Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.Trends in pharmacological sciences · 2011Review
- Pathogen-specific TLR2 protein activation programs macrophages to induce Wnt-beta-catenin signaling.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) derived from the inducible NO synthase (iNOS) is an important and complex mediator of inflammation in the intestine. Wnt-inducible secreted protein (WISP)-1 (CCN4), a member of the connective tissue growth factor family, is involved in tissue repair. We sought to determine the relationship between iNOS and WISP-1 in colitis. By analyzing human colonic biopsy samples, we showed that the expression of mRNA for both iNOS and WISP-1 was significantly higher in ulcerative colitis samples compared with control tissue. The upregulation of WISP-1 was positively correlated with iNOS expression in two models of colitis, induced by intrarectal trinitrobenzenesulfonic acid (TNBS) or occurring spontaneously in IL-10 deficient mice. Loss of iNOS, studied using iNOS(-/-) mice in both TNBS-induced and IL-10(-/-) colitis models, significantly attenuated the colitis-related WISP-1 increase. In human colonic epithelial cell lines, the NO donor, DETA-NONOate, elevated WISP-1 mRNA and protein expression through a beta-catenin and CREB-dependent, but Wnt-1-independent, pathway. In addition, NO-induced WISP-1 directly induced secretion of soluble collagen in colonic fibroblast cells. NO increases WISP-1 expression both in vitro and in vivo, suggesting a new role for iNOS and NO in colitis.
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