Evidence map›Paper›PMID 19238251›Full record

ArticleBioinformation2008

FlexPred: a web-server for predicting residue positions involved in conformational switches in proteins.

Igor B Kuznetsov, Michael McDuffie

Abstract read
In one paragraph

Article in Bioinformation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Characterization of SdGA, a cold-adapted glucoamylase fromBiotechnology reports (Amsterdam, Netherlands) · 2021
    Article
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  7. Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  8. Article
  9. Protein flexibility in the light of structural alphabets.Frontiers in molecular biosciences · 2015
    Review
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Igor B KuznetsovGenNY*sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, One Discovery Drive, University at Albany, Rensselaer, NY 12144, USA. ikuznetsov@albany.edu
Michael McDuffie

Funding

Computational methods for the analysis of protein flexibility.R03LM009034 · NLM · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI KUZNETSOV, IGOR B. · 2006 to 2007
$141k
NLM NIH HHS R03 LM009034
6 · The paper itself

Abstract

unlabelledConformational switches observed in the protein backbone play a key role in a variety of fundamental biological activities. This paper describes a web-server that implements a pattern recognition algorithm trained on the examples from the Database of Macromolecular Movements to predict residue positions involved in conformational switches. Prediction can be performed at an adjustable false positive rate using a user-supplied protein sequence in FASTA format or a structure in a Protein Data Bank (PDB) file. If a protein sequence is submitted, then the web-server uses sequence-derived information only (such as evolutionary conservation of residue positions). If a PDB file is submitted, then the web-server uses sequence-derived information and residue solvent accessibility calculated from this file. AVAILABILITY: FlexPred is publicly available at http://flexpred.rit.albany.edu.

Indexed as

conformational variabilitypredictionprotein flexibilitystructural transitionsupport vector machine

Identifiers

PMID19238251
PMCPMC2639688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.