ArticleObesity (Silver Spring, Md.)2009
Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa.
Article in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A stop-gain variant inHGG advances · 2023Pooled it
- The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging.Neuroscience and biobehavioral reviews · 2023Review
- Review
- Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels.Journal of human genetics · 2021Article
- Genomics of body fat distribution.Journal of genetics · 2021Review
- A missense variant in CREBRF is associated with taller stature in Samoans.American journal of human biology : the official journal of the Human Biology Council · 2020Article
- 12q14 microduplication: a new clinical entity reciprocal to the microdeletion syndrome?BMC medical genomics · 2020Article
- A thrifty variant in CREBRF strongly influences body mass index in Samoans.Nature genetics · 2016Article
- The contribution of feeding mode to obesogenic growth trajectories in American Samoan infants.Pediatric obesity · 2014Article
- Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.Cell reports · 2013Article
- INSIG2 variants, dietary patterns and metabolic risk in Samoa.European journal of clinical nutrition · 2013Article
- Epigenetics, and human biology and health responses to modernization in the Samoan archipelago.Collegium antropologicum · 2012Article
- Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders.Epigenetics · 2011Article
- Ecological and sociodemographic effects on urinary catecholamine excretion in adult Samoans.Annals of human biology · 2011Article
- A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.BMC medical genetics · 2009Article
- Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands.BMC medical genetics · 2009Article
- Dietary patterns are associated with metabolic syndrome in adult Samoans.The Journal of nutrition · 2009Article
- Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.Human biology · 2008Article
- Behavioral and perceived stressor effects on urinary catecholamine excretion in adult Samoans.American journal of human biology : the official journal of the Human Biology CouncilArticle
- Modernization and cardiometabolic risk in Samoan adolescents.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Obesity is a complex phenotype affected by genetic and environmental influences such as sociocultural factors and individual behaviors. Previously, we performed two separate genome-wide investigations for adiposity-related traits (BMI, percentage body fat (%BF), abdominal circumference (ABDCIR), and serum leptin and serum adiponectin levels) in families from American Samoa and in families from Samoa. The two polities have a common evolutionary history but have lately been influenced by variations in economic development, leading to differences in income and wealth and in dietary and physical activity patterns. We now present a genome-wide linkage scan of the combined samples from the two polities. We adjust for environmental covariates, including polity of residence, education, cigarette smoking, and farm work, and use variance component methods to calculate univariate and bivariate multipoint lod scores. We identified a region on 9p22 with genome-wide significant linkage for the bivariate phenotypes ABDCIR-%BF (1-d.f. lod 3.30) and BMI-%BF (1-d.f. lod 3.31) and two regions with genome-wide suggestive linkage on 8p12 and 16q23 for adiponectin (lod 2.74) and the bivariate phenotype leptin-ABDCIR (1-d.f. lod 3.17), respectively. These three regions have previously been reported to be linked to adiposity-related phenotypes in independent studies. However, the differences in results between this study and our previous polity-specific studies suggest that environmental effects are of different importance in the samples. These results strongly encourage further genetic studies of adiposity-related phenotypes where extended sets of carefully measured environmental factors are taken into account.
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