ArticleLearning & memory (Cold Spring Harbor, N.Y.)2009
Chronic enhancement of CREB activity in the hippocampus interferes with the retrieval of spatial information.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 82 citations in OpenAlex.
- The universal role of adaptive transcription in health and disease.The FEBS journal · 2025Review
- Enhancement of physiology via adaptive transcription.Pflugers Archiv : European journal of physiology · 2025Review
- Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability.Science advances · 2024Article
- Latent toxoplasmosis impairs learning and memory yet strengthens short-term and long-term hippocampal synaptic plasticity at perforant pathway-dentate gyrus, and Schaffer collatterals-CA1 synapses.Scientific reports · 2023Article
- The CBP KIX domain regulates long-term memory and circadian activity.BMC biology · 2020Article
- Article
- Noncanonical Roles of hNeural plasticity · 2020Article
- CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis.Brain, behavior, and immunity · 2019Review
- Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability.Biological psychiatry · 2019Article
- ENOblock inhibits the pathology of diet-induced obesity.Scientific reports · 2019Article
- Memory Allocation: Mechanisms and Function.Annual review of neuroscience · 2018Review
- Molecular correlates of separate components of training that contribute to long-term memory formation after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia.Frontiers in molecular neuroscience · 2018Review
- CREB, cellular excitability, and cognition: Implications for aging.Behavioural brain research · 2017Review
- Article
- Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- AFrontiers in behavioral neuroscience · 2017Article
- Subhypnotic doses of propofol impair spatial memory retrieval in rats.Neural regeneration research · 2016Article
- Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.Molecular psychiatry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The activation of cAMP-responsive element-binding protein (CREB)-dependent gene expression is thought to be critical for the formation of different types of long-term memory. To explore the consequences of chronic enhancement of CREB function on spatial memory in mammals, we examined spatial navigation in bitransgenic mice that express in a regulated and restricted manner a constitutively active form of CREB, VP16-CREB, in forebrain neurons. We found that chronic enhancement of CREB activity delayed the acquisition of an allocentric strategy to solve the hidden platform task. The ability to turn on and off transgene expression allowed us to dissect the role of CREB in dissociable memory processes. In mice in which transgene expression was turned on during memory acquisition, turning off the transgene re-established the access to the memory trace, whereas in mice in which transgene expression was turned off during acquisition, turning on the transgene impaired memory expression in a reversible manner, indicating that CREB enhancement specifically interfered with the retrieval of spatial information. The defects on spatial navigation in mice with chronic enhancement of CREB function were not corrected by conditions that increased further CREB-dependent activation of hippocampal memory systems, such as housing in an enriched environment. These results along with previous findings in CREB-deficient mutants indicate that the relationship of CREB-mediated plasticity to spatial memory is an inverted-U function, and that optimal learning in the water maze requires accurate regulation of this pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.