ArticleCarcinogenesis2009
Sensitivity to NNKOAc is associated with renal cancer risk.
Article in Carcinogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Racial Disparities and Preventive Measures to Renal Cell Carcinoma.International journal of environmental research and public health · 2018Pooled it
- Kidney cancer burden in China from 1990 to 2023: A retrospective population-based observational study.The Journal of international medical research · 2026Observational
- Antidiabetic, Antiglycation, and Antioxidant Activities of Ethanolic Seed Extract ofMolecules (Basel, Switzerland) · 2022Article
- Coffee intake and trace element blood concentrations in association with renal cell cancer among smokers.Cancer causes & control : CCC · 2022Article
- Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro.Biomedicines · 2021Article
- Association between ACYP2 polymorphisms and the risk of renal cell cancer.Molecular genetics & genomic medicine · 2019Article
- Prognostic biomarkers in renal cell carcinoma: is there a relationship with obesity?Translational andrology and urology · 2019Review
- Duration-dependent effects of nicotine exposure on growth and AKT activation in human kidney epithelial cells.Molecular and cellular biochemistry · 2018Article
- High expression ofJournal of Cancer · 2018Article
- Renal cell carcinoma: links and risks.International journal of nephrology and renovascular disease · 2016Review
- Epidemiology and staging of renal cell carcinoma.Seminars in interventional radiology · 2014Review
- Comprehensive assessment of the impact of cigarette smoking on survival of clear cell kidney cancer.The Journal of urology · 2014Article
- The epidemiology and risk factors for renal cancer.Current urology · 2013Review
- Epidemiology and risk factors for kidney cancer.Nature reviews. Urology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Cigarette smoking has been investigated as a major risk factor for renal cell carcinoma (RCC). 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most abundant carcinogenic N-nitrosamines present in cigarette smoke. However, the association between repair capacity of NNK-induced DNA damage and RCC risk remains unknown. We used the comet assay to assess whether sensitivity to a NNK precursor 4-[(acetoxymethyl) nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc) induced DNA damage, which partly reflects host sensitivity to NNK, was associated with increased risk of RCC in a population-based case-control study. The study included 95 RCC cases and 188 matched controls. Epidemiologic data were collected via in-person interview. Baseline and NNK-induced DNA damage in peripheral blood lymphocytes were measured using the comet assay and quantified by the Olive tail moment. The NNKOAc-induced median Olive tail moments were significantly higher in cases than in controls (2.27 versus 1.76, P = 0.002). Using the 75th percentile Olive tail moments of the controls as the cutoff point, we found that higher levels of NNKOAc-induced DNA damage were associated with a significantly increased risk of RCC [odds ratio, 2.06; 95% confidence interval, 1.17-3.61]. In quartile analysis, there was a dose-response association between NNKOAc-induced damage and risk of RCC (P for trend, 0.006). Our data strongly suggest that higher levels of NNKOAc-induced damage are associated with higher risks of RCC. Future studies with larger sample sizes are warranted to further investigate whether repair of NNKOAc-induced damage, as quantified by the comet assay, could be used as a predictive marker for RCC risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.