ArticleProceedings of the National Academy of Sciences of the United States of America2009
Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia.International journal of molecular sciences · 2024Article
- Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response.Genetics · 2023Article
- Ubiquitin is a carbon dioxide-binding protein.Science advances · 2021Article
- ECCOFrontiers in medicine · 2021Article
- Hypercapnia: An Aggravating Factor in Asthma.Journal of clinical medicine · 2020Review
- The role of carbon dioxide in nematode behaviour and physiology.Parasitology · 2020Review
- AMP-Activated Protein Kinase (AMPK) at the Crossroads Between COInternational journal of molecular sciences · 2020Review
- Hypercapnia Regulates Gene Expression and Tissue Function.Frontiers in physiology · 2020Review
- Hypercapnia-Driven Skeletal Muscle Dysfunction in an Animal Model of Pulmonary Emphysema Suggests a Complex Phenotype.Frontiers in physiology · 2020Article
- Workplace exposure to carbon dioxide during routine laparoscopy - is it safe?F1000Research · 2020Article
- Elevated COScientific reports · 2019Article
- Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA.Communications biology · 2019Article
- A Proteomic Analysis Provides Novel Insights into the Stress Responses of Caenorhabditis elegans towards Nematicidal Cry6A Toxin from Bacillus thuringiensis.Scientific reports · 2017Article
- A Single Set of Interneurons Drives Opposite Behaviors in C. elegans.Current biology : CB · 2017Article
- Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into COThe Journal of biological chemistry · 2017Article
- Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.Intensive care medicine · 2017Article
- Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.Genes & development · 2016Article
- Environmental CO2 inhibits Caenorhabditis elegans egg-laying by modulating olfactory neurons and evokes widespread changes in neural activity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Gas sensing in nematodes.Molecular neurobiology · 2015Review
- The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.PLoS genetics · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
Hypercapnia (high CO(2) levels) occurs in a number of lung diseases and it is associated with worse outcomes in patients with chronic obstructive lung disease (COPD). However, it is largely unknown how hypercapnia is sensed and responds in nonneuronal cells. Here, we used C. elegans to study the response to nonanesthetic CO(2) levels and show that levels exceeding 9% induce aberrant motility that is accompanied by age-dependent deterioration of body muscle organization, slowed development, reduced fertility and increased life span. These effects occur independently of the IGF-R, dietary restriction, egg laying or mitochondrial-induced aging pathways. Transcriptional profiling analysis shows specific and dynamic changes in gene expression after 1, 6, or 72 h of exposure to 19% CO(2) including increased transcription of several 7-transmembrane domain and innate immunity genes and a reduction in transcription of many of the MSP genes. Together, these results suggest specific physiological and molecular responses to hypercapnia, which appear to be independent of early heat shock and HIF mediated pathways.
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