ArticleMolecular and cellular biology2009
E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Expression of the three components of linear ubiquitin assembly complex in breast cancer.PloS one · 2018Trial
- DNA damage repair factor Rad18 controls virulence partially via transcriptional suppression of genesVirulence · 2024Article
- Wnt/β-catenin signaling pathway in the tumor progression of adrenocortical carcinoma.Frontiers in endocrinology · 2023Review
- A Z-Linked E3 Ubiquitin LigaseAnimals : an open access journal from MDPI · 2021Article
- The E3 Ubiquitin Ligase HOIP inhibits Cancer Cell Apoptosis via modulating PTEN stability.Journal of Cancer · 2021Article
- Current knowledge on the acute regulation of steroidogenesis.Biology of reproduction · 2018Review
- MicroRNA-378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma.Oncology letters · 2018Article
- The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.JCI insight · 2017Article
- HIDEEP: a systems approach to predict hormone impacts on drug efficacy based on effect paths.Scientific reports · 2017Article
- Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.Cell · 2017Article
- Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression.BMC cancer · 2016Review
- Article
- The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation.Oncogene · 2014Article
- A design principle underlying the paradoxical roles of E3 ubiquitin ligases.Scientific reports · 2014Article
- RBR E3-ligases at work.EMBO reports · 2014Review
- Genome-wide identification and characterization of RBR ubiquitin ligase genes in soybean.PloS one · 2014Article
- Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport.Biology open · 2012Article
- Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.Molecular endocrinology (Baltimore, Md.) · 2012Article
- A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.Journal of lipids · 2012Article
- Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic and experimental evidence points to a critical involvement of the atypical mammalian orphan receptor DAX-1 in reproductive development and steroidogenesis. Unlike conventional nuclear receptors, DAX-1 appears not to function as a DNA-bound transcription factor. Instead, it has acquired the capability to act as a transcriptional corepressor of steroidogenic factor 1 (SF-1). The interplay of DAX-1 and SF-1 is considered a central, presumably ligand-independent element of adrenogonadal development and function that requires tight regulation. This raises a substantial interest in identifying its modulators and the regulatory signals involved. Here, we uncover molecular mechanisms that link DAX-1 to the ubiquitin modification system via functional interaction with the E3 ubiquitin ligase RNF31. We demonstrate that RNF31 is coexpressed with DAX-1 in steroidogenic tissues and participates in repressing steroidogenic gene expression. We provide evidence for the in vivo existence of a corepressor complex containing RNF31 and DAX-1 at the promoters of the StAR and CYP19 genes. Our data suggest that RNF31 functions to stabilize DAX-1, which might be linked to DAX-1 monoubiquitination. In conclusion, RNF31 appears to be required for DAX-1 to repress transcription, provides means to regulate DAX-1 in ligand-independent ways, and emerges as a relevant coregulator of steroidogenic pathways governing physiology and disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.