ArticleInfection and immunity2009
Contribution of Bordetella bronchiseptica filamentous hemagglutinin and pertactin to respiratory disease in swine.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- First inhibitor of a bacterial two-partner secretion system.bioRxiv : the preprint server for biology · 2026Article
- Bordetellae colonization oligosaccharide (b-Cool), a glycan crucial for nasal colonization.Science advances · 2025Article
- Genetic diversity ofFrontiers in microbiology · 2025Article
- Effect of carbohydrates on the adhesion of Bordetella bronchiseptica to the respiratory epithelium in rabbits.Veterinary research communications · 2024Article
- Comparative analysis of antimicrobial resistance and genetic diversity ofFrontiers in microbiology · 2024Article
- Review
- Shifts in the swine nasal microbiota followingFrontiers in microbiology · 2023Article
- The use of filamentous hemagglutinin adhesin to detect immune responses toFrontiers in veterinary science · 2022Article
- Bordetella bronchiseptica promotes adherence, colonization, and cytotoxicity of Streptococcus suis in a porcine precision-cut lung slice model.Virulence · 2021Article
- Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin.Virulence · 2021Article
- Pertactin contributes to shedding and transmission of Bordetella bronchiseptica.PLoS pathogens · 2021Article
- Coinfections and their molecular consequences in the porcine respiratory tract.Veterinary research · 2020Review
- Complete Genome Sequence of Bordetella bronchiseptica Strain KM22.Microbiology resource announcements · 2020Article
- Article
- Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence.The Journal of antimicrobial chemotherapy · 2018Article
- Article
- An Extracellular Polysaccharide Locus Required for Transmission of Bordetella bronchiseptica.The Journal of infectious diseases · 2017Article
- The Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine.Infection and immunity · 2017Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22.Veterinary microbiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bordetella bronchiseptica is pervasive in swine populations and plays multiple roles in respiratory disease. Most studies addressing virulence factors of B. bronchiseptica are based on isolates derived from hosts other than pigs. Two well-studied virulence factors implicated in the adhesion process are filamentous hemagglutinin (FHA) and pertactin (PRN). We hypothesized that both FHA and PRN would serve critical roles in the adhesion process and be necessary for colonization of the swine respiratory tract. To investigate the role of FHA and PRN in Bordetella pathogenesis in swine, we constructed mutants containing an in-frame deletion of the FHA or the PRN structural gene in a virulent B. bronchiseptica swine isolate. Both mutants were compared to the wild-type swine isolate for their ability to colonize and cause disease in swine. Colonization of the FHA mutant was lower than that of the wild type at all respiratory tract sites and time points examined and caused limited to no disease. In contrast, the PRN mutant caused similar disease severity relative to the wild type; however, colonization of the PRN mutant was reduced relative to the wild type during early and late infection and induced higher anti-Bordetella antibody titers. Together, our results indicate that despite inducing different pathologies and antibody responses, both FHA and PRN are necessary for optimal colonization of the swine respiratory tract.
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