ArticleInfection and immunity2009
Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 99 citations in OpenAlex.
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- Probiotic, Paraprobiotic, and Postbiotic Activities ofInternational journal of molecular sciences · 2025Article
- Epitope mapping of recombinant Salmonella enterica serotype Heidelberg flagellar hook-associated protein by in silico and in vivo approaches.BMC veterinary research · 2025Article
- Exopolysaccharide production by seven basidiomycetous fungi and their antioxidant and immunomodulatory activities againstFrontiers in cellular and infection microbiology · 2025Article
- Probiotic Potential of Yeasts Isolated from Fermented Beverages: Assessment of Antagonistic Strategies AgainstJournal of fungi (Basel, Switzerland) · 2024Article
- Gut epithelial electrical cues drive differential localization of enterobacteria.Nature microbiology · 2024Article
- Secretome analysis of an environmental isolate Enterobacter sp. S-33 identifies proteins related to pathogenicity.Archives of microbiology · 2022Article
- Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection.Nature microbiology · 2022Article
- Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes.Cell host & microbe · 2022Article
- Therapeutic effects of oral administration of lyticFrontiers in microbiology · 2022Article
- Article
- Single Cell Analysis of Bistable Expression of Pathogenicity Island 1 and the Flagellar Regulon inMicroorganisms · 2021Article
- Bacterial Manipulation of the Integrated Stress Response: A New Perspective on Infection.Frontiers in microbiology · 2021Review
- Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes.PLoS pathogens · 2020Article
- Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.The Journal of experimental medicine · 2019Article
- Crosslinked flagella as a stabilized vaccine adjuvant scaffold.BMC biotechnology · 2019Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Salmonella enterica serotype Typhimurium causes acute inflammatory diarrhea in humans. Flagella contribute to intestinal inflammation, but the mechanism remains unclear since most mutations abrogating pattern recognition of flagellin also prevent motility and reduce bacterial invasion. To determine the contribution of flagellin pattern recognition to the generation of innate immune responses, we compared in two animal models a nonmotile, but flagellin-expressing and -secreting serotype Typhimurium strain (flgK mutant) to a nonmotile, non-flagellin-expressing strain (flgK fliC fljB mutant). In vitro, caspase-1 can be activated by cytosolic delivery of flagellin, resulting in release of the interferon gamma inducing factor interleukin-18 (IL-18). Experiments with streptomycin-pretreated caspase-1-deficient mice suggested that induction of gamma interferon expression in the murine cecum early (12 h) after serotype Typhimurium infection was caspase-1 dependent but independent of flagellin pattern recognition. In addition, mRNA levels of the CXC chemokines macrophage inflammatory protein 2 and keratinocyte-derived chemokine were markedly increased early after serotype Typhimurium infection of streptomycin-pretreated wild-type mice regardless of flagellin expression. In contrast, in bovine ligated ileal loops, flagellin pattern recognition contributed to increased mRNA levels of macrophage inflammatory protein 3alpha and more fluid accumulation at 2 h after infection. Collectively, our data suggest that pattern recognition of flagellin contributes to early innate host responses in the bovine ileal mucosa but not in the murine cecal mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.