ArticleInfection and immunity2009
Yersinia pestis IS1541 transposition provides for escape from plague immunity.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Protective outcomes of high-affinity monoclonal antibodies against drug-resistant plague strains.Frontiers in immunology · 2026Article
- Evidence of a role for the F1 capsule ofmBio · 2025Article
- Live Plague Vaccine Development: Past, Present, and Future.Vaccines · 2025Review
- Article
- Antibiotic Therapy of Plague: A Review.Biomolecules · 2021Review
- Plague vaccine: recent progress and prospects.NPJ vaccines · 2019Review
- A cis-encoded sRNA, Hfq and mRNA secondary structure act independently to suppress IS200 transposition.Nucleic acids research · 2015Article
- Article
- Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Hereditary hemochromatosis restores the virulence of plague vaccine strains.The Journal of infectious diseases · 2012Article
- Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity.Infection and immunity · 2012Article
- Substrates of the plasminogen activator protease of Yersinia pestis.Advances in experimental medicine and biology · 2012Review
- An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague.PLoS neglected tropical diseases · 2012Article
- Article
- Plague in Guinea pigs and its prevention by subunit vaccines.The American journal of pathology · 2011Article
- Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence.Microbiology (Reading, England) · 2011Article
- The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background.Infection and immunity · 2011Article
- Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium.Journal of bacteriology · 2010Article
- Irradiation-induced Deinococcus radiodurans genome fragmentation triggers transposition of a single resident insertion sequence.PLoS genetics · 2010Article
- Draft genome sequences of Yersinia pestis isolates from natural foci of endemic plague in China.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Yersinia pestis is perhaps the most feared infectious agent due to its ability to cause epidemic outbreaks of plague disease in animals and humans with high mortality. Plague infections elicit strong humoral immune responses against the capsular antigen (fraction 1 [F1]) of Y. pestis, and F1-specific antibodies provide protective immunity. Here we asked whether Y. pestis generates mutations that enable bacterial escape from protective immunity and isolated a variant with an IS1541 insertion in caf1A encoding the F1 outer membrane usher. The caf1A::IS1541 insertion prevented assembly of F1 pili and provided escape from plague immunity via F1-specific antibodies without a reduction in virulence in mouse models of bubonic or pneumonic plague. F1-specific antibodies interfere with Y. pestis type III transport of effector proteins into host cells, an inhibitory effect that was overcome by the caf1A::IS1541 insertion. These findings suggest a model in which IS1541 insertion into caf1A provides for reversible changes in envelope structure, enabling Y. pestis to escape from adaptive immune responses and plague immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.