ArticleNucleic acids research1991
An X-linked zinc finger gene mapping to Xq21.1-q21.3 closely related to ZFX and ZFY: possible origins from a common ancestral gene.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure.Protein science : a publication of the Protein Society · 2024Article
- Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure.bioRxiv : the preprint server for biology · 2024Article
- Detection of chromosome x;18 breakpoints and translocation of the xq22.3;18q23 regions resulting in variable fertility phenotypes.Case reports in genetics · 2012Article
- Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Localisation of two candidate genes for mental retardation using a YAC physical map of the Xq21.1-21.2 subbands.Journal of medical genetics · 1996Article
- A ZFY-like sequence in fish, with comments on the evolution of the ZFY family of genes in vertebrates.Biochemical genetics · 1995Article
- A rearrangement on chromosome 5 of an expressed human beta-glucuronidase pseudogene.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc.Chromosoma · 1994Article
- Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.Molecular and cellular biology · 1994Article
- A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
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6 authors at 1 institution in 1 country.
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Abstract
We describe a new zinc finger gene sequence (CMPX1 or HGM symbol ZNF6; isolated by cross-hybridization of ZFY to clones in a testis cDNA library) which possesses a zinc finger domain closely related to the transcriptional activator gene ZFX. The putative acidic activation domain is only 11.5% homologous with ZFX, whereas the putative DNA binding domain shares 75% homology and shows the same organisation composed of a basic two fingered repeat unit. ZNF6 has an unusually large 5' untranslated region (UTR) of 1.2 Kb which contains 26 potential ATG initiation codons, only one of which is associated with a long open reading frame. Southern and Northern blot analysis has shown that this 5' UTR is shared with many other sequences in the genome and transcribed associated with a large range of mRNA species. In situ hybridisation, analysis of somatic cell hybrids and male individuals carrying deleted X chromosomes have mapped the gene to Xq21.1-q21.3. The gene is highly conserved amongst the primates, in the mouse and can be detected weakly in the genome of a metatherian mammal (possum). Dosage in male and female mice indicates that it is also X-linked in this species. Possible origins of ZFX, ZFY and CMPX1 from a common ancestral gene are discussed.
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