ArticleInfection and immunity2009
Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Gastric cancer burden and regional disparities among Helicobacter pylori-positive patients in the Americas: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Global diversity of integrating conjugative elements (ICEs) inbioRxiv : the preprint server for biology · 2025Article
- Comparative genomic analysis of Helicobacter pylori isolates from gastric cancer and gastritis in China.BMC cancer · 2025Article
- Integrative and Conjugative Elements ofFrontiers in cellular and infection microbiology · 2020Article
- Rearrangement analysis of multiple bacterial genomes.BMC bioinformatics · 2019Article
- Phylogeographic diversity and mosaicism of theMobile DNA · 2018Article
- Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) DiseasesAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Article
- Protein signature characterizingInfectious agents and cancer · 2017Article
- The distribution of jhp0940, jhp0945, jhp0947, jhp0949 and jhp0951 genes of Helicobacter pylori in China.BMC gastroenterology · 2015Article
- Gastric cancer research in Mexico: a public health priority.World journal of gastroenterology · 2014Review
- Exploration of the genomic diversity and core genome of the Bifidobacterium adolescentis phylogenetic group by means of a polyphasic approach.Applied and environmental microbiology · 2013Article
- Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects.Asian Pacific journal of tropical biomedicine · 2012Article
- Role of Helicobacter pylori plasticity region genes in development of gastroduodenal diseases.Journal of clinical microbiology · 2012Article
- Comparative genomics of Helicobacter pylori strains of China associated with different clinical outcome.PloS one · 2012Article
- Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan.BMC gastroenterology · 2011Article
- Pathogenicity island cag, vacA and IS605 genotypes in Mexican strains of Helicobacter pylori associated with peptic ulcers.Annals of clinical microbiology and antimicrobials · 2011Article
- Article
- Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Helicobacter pylori establishes a chronic infection in the human stomach, causing gastritis, peptic ulcer, or gastric cancer, and more severe diseases are associated with virulence genes such as the cag pathogenicity island (PAI). The aim of this work was to study gene content differences among H. pylori strains isolated from patients with different gastroduodenal diseases in a Mexican-Mestizo patient population. H. pylori isolates from 10 patients with nonatrophic gastritis, 10 patients with duodenal ulcer, and 9 patients with gastric cancer were studied. Multiple isolates from the same patient were analyzed by randomly amplified polymorphic DNA analysis, and strains with unique patterns were tested using whole-genome microarray-based comparative genomic hybridization (aCGH). We studied 42 isolates and found 1,319 genes present in all isolates, while 341 (20.5%) were variable genes. Among the variable genes, 127 (37%) were distributed within plasticity zones (PZs). The overall number of variable genes present in a given isolate was significantly lower for gastric cancer isolates. Thirty genes were significantly associated with nonatrophic gastritis, duodenal ulcer, or gastric cancer, 14 (46.6%) of which were within PZs and the cag PAI. Two genes (HP0674 and JHP0940) were absent in all gastric cancer isolates. Many of the disease-associated genes outside the PZs formed clusters, and some of these genes are regulated in response to acid or other environmental conditions. Validation of candidate genes identified by aCGH in a second patient cohort allowed the identification of novel H. pylori genes associated with gastric cancer or duodenal ulcer. These disease-associated genes may serve as biomarkers of the risk for severe gastroduodenal diseases.
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