ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2009
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Glucocorticoids alleviate particulate matter-induced COX-2 expression and mitochondrial dysfunction through the Bcl-2/GR complex in A549 cells.Scientific reports · 2023Article
- Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PMEnvironmental pollution (Barking, Essex : 1987) · 2021Article
- Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation.Aging · 2018Article
- SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Particulate matter 2.5 induces autophagy via inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin kinase signaling pathway in human bronchial epithelial cells.Molecular medicine reports · 2015Article
- FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction.Oncogene · 2015Article
- Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.American journal of respiratory cell and molecular biology · 2015Article
- Source of biomass cooking fuel determines pulmonary response to household air pollution.American journal of respiratory cell and molecular biology · 2014Article
- Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1.The American journal of pathology · 2013Article
- Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.Nature immunology · 2013Article
- Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation.Particle and fibre toxicology · 2012Article
- Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.Scientific reports · 2012Article
- Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity.Biochemistry research international · 2012Article
- Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.Nano letters · 2011Article
- Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.Particle and fibre toxicology · 2011Article
- Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.PloS one · 2011Article
- Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance.Respirology (Carlton, Vic.) · 2011Article
- Update in environmental and occupational medicine 2009.American journal of respiratory and critical care medicine · 2010Review
- Enhanced death signaling in ozone-exposed ischemic-reperfused hearts.Molecular and cellular biochemistry · 2010Article
- Satellite-based PM concentrations and their application to COPD in Cleveland, OH.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Elevated ambient levels of particulate matter air pollution are associated with excess daily mortality, largely attributable to increased rates of cardiovascular events. We have previously reported that particulate matter induces p53-dependent apoptosis in primary human alveolar epithelial cells. Activation of the intrinsic apoptotic pathway by p53 often requires the transcription of the proapoptotic Bcl-2 proteins Noxa, Puma, or both. In this study, we exposed alveolar epithelial cells in culture and mice to fine particulate matter <2.5 microm in diameter (PM(2.5)) collected from the ambient air in Washington, D. C. Exposure to PM(2.5) induced apoptosis in primary alveolar epithelial cells from wild-type but not Noxa(-/-) mice. Twenty-four hours after the intratracheal instillation of PM(2.5), wild-type mice showed increased apoptosis in the lung and increased levels of mRNA encoding Noxa but not Puma. These changes were associated with increased permeability of the alveolar-capillary membrane and inflammation. All of these findings were absent or attenuated in Noxa(-/-) animals. We conclude that PM(2.5)-induced cell death requires Noxa both in vitro and in vivo and that Noxa-dependent cell death might contribute to PM-induced alveolar epithelial dysfunction and the resulting inflammatory response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.